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EC number: 233-912-4 | CAS number: 10431-98-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- no
- Remarks:
- In house study in non-GLP facility
- Analytical monitoring:
- yes
- Buffers:
- the solutions contained 0.005M KHP as a buffer
- Details on test conditions:
- A jacketed beaker filled with DI water was heated and maintained at 37°C using an immersion heater and pump. The immersion heater was placed in a 3-gallon reservoir of water and controlled using the temperature control unit. The thermocouple was suspended in the jacketed beaker next to the sample being hydrolyzed, to ensure the temperature the sample was exposed. Samples were taken from the sample vial thru the septa using a clean and dried stainless-steel needle at desired time intervals and at time zero.
The sample aliquots removed (1mL) from the reaction mixture were analyzed using gas chromatography. An internal procedure was used to calibrate the GC to correlate the weight percent in each sample compared to peak area from the eluted peak in the chromatogram; the internal standard used was acetone. The analysis conducted targets the degradation of the 2-ethyl-oxazoline through a hydrolytic process at varying pH, and does not monitor the formation of the hydrolyzed products. - Duration:
- 6.5 h
- pH:
- 2.98
- Temp.:
- 37 °C
- Duration:
- 6.33 h
- pH:
- 6.98
- Temp.:
- 37 °C
- Duration:
- 6.3 h
- pH:
- 10
- Temp.:
- 37 °C
- Transformation products:
- not measured
- Key result
- pH:
- 2.98
- Temp.:
- 37 °C
- Hydrolysis rate constant:
- 0.103 h-1
- DT50:
- 6.73 h
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 6.98
- Temp.:
- 37 °C
- Hydrolysis rate constant:
- 0.167 h-1
- DT50:
- 4.14 h
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 10
- Temp.:
- 37 °C
- Hydrolysis rate constant:
- 0.052 h-1
- DT50:
- 13.36 h
- Type:
- (pseudo-)first order (= half-life)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The test substance undergoes hydrolysis in contact with water.
At pH 2.98 T1/2 = 6.73 hours
At pH 6.98 T1/2 = 4.14 hours
At pH 10.00 T1/2 = 13.36 hours
Reference
Description of key information
The test substance undergoes hydrolysis in contact with water.
At pH 2.98 T1/2 = 6.73 hours
At pH 6.98 T1/2 = 4.14 hours
At pH 10.00 T1/2 = 13.36 hours
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 4.14 h
- at the temperature of:
- 37 °C
Additional information
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