Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1959
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1959
Report Date:
1959

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remark on MMAD/GSD:
not specified
Details on inhalation exposure:
single inhalation exposure
Analytical verification of test atmosphere concentrations:
not specified
Remarks on duration:
4hours
Concentrations:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LC50
Effect level:
>= 5.8 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Key result
Sex:
not specified
Dose descriptor:
LC50
Effect level:
>= 1 700 ppm
Based on:
test mat.
Exp. duration:
4 h
Mortality:
not specified
Clinical signs:
other: not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Conclusions:
The LC50 of 2-methylfuran (4h) was determined to be 5.8 mg/L (1700 ppm) in an inhalation toxicity study of a single 4 hours exposure to rats.
Executive summary:

In an acute inhalation toxicity study rats were exposed to 2-methylfuran in a single application over 4 hours.

No further details on the study design were given and it was not specified if any guideline was followed.

The LC50 was determined to be 5.8 mg/L (1700 ppm) in this acute inhalation study. The test substance was rated as moderately toxic by the authors of the study.