Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1959
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1959
Report Date:
1959

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
not specified

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
undiluted 2-methylfuran
Duration of treatment / exposure:
24 h
Observation period:
not specified
Number of animals:
not specified
Details on study design:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
other: Irritation rating
Remarks:
no scoring performed
Basis:
other: all animals
Time point:
24 h
Reversibility:
not specified
Remarks on result:
probability of severe irritation
Irritant / corrosive response data:
Severely irritating
Other effects:
not specified

Applicant's summary and conclusion

Conclusions:
The skin irritation potential of 2-methylfuran was determined in a single 24 h application to rabbits. The substance was rated as severely irritating the skin of rabbits.
Executive summary:

The skin irritation potential of 2-methylfuran was determined in a single 24 h application to rabbits. Undiluted substance was in contact with the skin. No further details on the study design were given and it was not specified if any guideline was followed.

The substance was rated as severely irritating the skin of rabbits by the authors of the study. The irritation is distinctly associated with the ability of 2 -methylfuran to penetrate the skin, since more than merely surface irritation is involved.