Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1959
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1959
Report Date:
1959

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
small amounts undiluted.
Duration of treatment / exposure:
not specified
Observation period (in vivo):
not specified
Duration of post- treatment incubation (in vitro):
not specified
Number of animals or in vitro replicates:
not specified
Details on study design:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
other: Irritation Rating
Basis:
other: all animals
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Other effects:
not specified

Applicant's summary and conclusion

Conclusions:
The eye irritation potential of 2-methylfuran was determined in a single application to rabbits. The substance was rated as mildly irritating to the eyes of rabbits.
Executive summary:

The eye irritation potential of 2-methylfuran was determined in a single application to rabbits. Small amounts of undiluted 2 -methylfuran was used. No further details on the study design were given and it was not specified if any guideline was followed.

The substance was rated as mildly irritating the eyes of rabbits by the authors of the study.