Registration Dossier

Administrative data

Endpoint:
toxicity to microorganisms, other
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
DIN 38412-8 (Pseudomonas Zellvermehrungshemmtest)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
other: Bacteria: Pseudomonas putida and Protozoa: Entosiphon sulcatum

Study design

Test type:
static
Water media type:
not specified
Limit test:
no
Total exposure duration:
8 d

Test conditions

Test temperature:
25°C
Details on test conditions:
Type: aquatic

Results and discussion

Effect concentrationsopen allclose all
Duration:
8 d
Dose descriptor:
NOEC
Effect conc.:
90 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: cell multiplication inhibition
Remarks on result:
other: result for Pseudomonas putida
Duration:
8 d
Dose descriptor:
NOEC
Effect conc.:
107 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: cell multiplication inhibition
Remarks on result:
other: result for Entosiphon sulcatum

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
The toxicity of the substance towards bacteria and protozoa was assessed. The "toxicity treshold" values, equivalent to NOEC, are 90 mg/L and 107 mg/L for Pseudomonas putida (Bacteria) and Entosiphon sulcatum (Protozoa) respectively.
Executive summary:

The toxicity of 2 -methylfuran towards Pseudomonas putida (Bacteria) and Entosiphon sulcatum (Protozoa) was assessed in a cell multiplication test, with endpoint assessment of cell multiplication inhibition after 8 days exposure. The test material was tested in a series of concentrations in a static test (pH 7).The result of the test was reported as the 'Toxicity Threshold', which is defined as the lowest test concentration that resulted in < 3 % inhibition compared to the control. The toxic threshold is considered to be equivalent to the NOEC. The reported toxic tresholds (or NOEC-8days) are 90 mg/L and 107 mg/L for Pseudomonas putida (Bacteria) and Entosiphon sulcatum (Protozoa) respectively.