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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1959
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1959
Report Date:
1959

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
single oral dose, substance administered as 25% solution in oil corn
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Remarks:
25% solution in corn oil
Details on oral exposure:
single application
Doses:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 133 mg/kg bw
Based on:
test mat.
Mortality:
not specified
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Conclusions:
The LD50 of 2-methylfuran was determined to be 133 mg/kg bw in an acute oral toxicity study after single application to rats.
Executive summary:

In an acute oral toxicity study in rats a 25% solution of 2-methylfuran in corn oil was administered by oral gavage in a single application. No further details on the study design were given and it was not specified if any guideline was followed.

The LD50 was determined to be 133 mg/kg bw in this acute oral toxicity study. The test substance was rated as moderately toxic by the authors of the study.