Registration Dossier

Diss Factsheets

Physical & Chemical properties

Density

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
tap density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24 April 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Although a recognised guideline was followed, the study was not conducted under GLP conditions.
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Version / remarks:
02 October 2012
Deviations:
yes
Remarks:
Study was performed at (on average) 22 °C not 20.0 °C (as per guideline). Typical thermal expansion coefficients of solids are typically of the order of 10-5 °C-1. An average temperature delta of 2 °C is expected to be negligible.
GLP compliance:
no
Type of method:
pycnometer method
Dynamic viscosity of test material:
Not applicable, the test item is a solid.
Key result
Type:
tap density
Density:
0.96 g/cm³
Temp.:
22 °C
Remarks on result:
other: Mean Value
Remarks:
Mean value derived from the result of test 1 and test 2
Type:
tap density
Density:
0.98 g/cm³
Temp.:
22.1 °C
Remarks on result:
other: Test 1
Type:
tap density
Density:
0.94 g/cm³
Temp.:
21.9 °C
Remarks on result:
other: Test 2

Table 1:       Density Results

Tap Density

Test 1

Test 2

Mean

Mass of stoppered, 100 mL graduated cylinder (g)

98.25

94.24

 

Mass of graduated cylinder and test item (g)

107.76

106.28

 

Mass of test item (g)

9.51

12.04

 

Mass of graduated cylinder, test item and suspending solvent (g)

129.22

130.05

 

Mass of suspending solvent (g)

21.46

23.77

 

Density of suspending solvent at 22 °C

0.79

0.79

 

Volume of suspension (mL)

37.00

43.00

 

Volume of suspending solvent (mL)

27.30

30.24

 

Volume of test item

9.70

12.76

 

Tap Density of test item

0.98

0.94

0.96

Conclusions:
The mean tap density of the test item was determined to be 0.96 g/cm3 at 21.9 - 22.1 °C.
Executive summary:

OECD 109 – The tap density of the test item was determined utilising a procedure designed to be compatible with OECD 109 (adopted 02 October 2012).

Two determinations were carried out.  Aliquots of test item (9.5 – 12.04 g) were placed in a graduated cylinder and stoppered.  The cylinder, stopper and test item were weighed.  Suspending solvent (isopropyl alcohol) was added to the cylinder until the liquid level was above the suspended powder.  The stoppered cylinder was weighed again.  The graduated cylinder was then tapped multiple times.  The final suspension volume was measured and recorded using the liquid meniscus level as the final volume. The temperature of the suspension was then measured and recorded.

The mean tap density of the test item was determined to be 0.96 g/cm3 at 21.9 - 22.1 °C.

Description of key information

Tap Density: D = 0.96 g/cm3; OECD 109.; D McSherry (2018)

Key value for chemical safety assessment

Additional information

OECD 109 – The tap density of the test item was determined utilising a procedure designed to be compatible with OECD 109 (adopted 02 October 2012).

Two determinations were carried out.  Aliquots of test item (9.5 – 12.04 g) were placed in a graduated cylinder and stoppered.  The cylinder, stopper and test item were weighed.  Suspending solvent (isopropyl alcohol) was added to the cylinder until the liquid level was above the suspended powder.  The stoppered cylinder was weighed again.  The graduated cylinder was then tapped multiple times.  The final suspension volume was measured and recorded using the liquid meniscus level as the final volume. The temperature of the suspension was then measured and recorded.

The mean tap density of the test item was determined to be 0.96 g/cm3 at 21.9 - 22.1 °C.