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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From February 22, 2018 to March 17, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: A5 Surface Tension of Commission Regulation (EC) No 440/2008 of 30 May 2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: Method 115 of the OECD Guidelines for the Testing of Chemicals, 27 July 1995
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
other: Ring method
Key result
Water solubility:
7.9 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
306.2 mg/L
Temp.:
20 °C
Remarks on result:
other: pH not specified

Results

The readings and temperatures for the sample solutions are shown in the following table:

Concentration (mg/L)

Reading (mN/m)

Temperature (°C)

1.021 x 103

31.0

20.0

30.5

20.0

30.5

20.0

306.2

31.0

20.0

30.5

20.0

30.5

20.0

102.1

31.0

20.0

31.0

20.0

31.0

20.0

30.62

31.5

20.0

31.5

20.0

31.5

20.0

10.21

34.5

20.0

34.5

20.0

35.0

20.0

3.062

42.0

20.0

42.0

20.0

42.5

20.0

1.021

54.5

20.0

55.0

20.0

55.0

20.0

0.3062

71.0

20.0

71.0

20.0

71.0

20.0

0.1021

72.0

20.0

71.5

20.0

71.5

20.0

 

Theconcentration (mg/L), log10[concentration (mg/L)] and mean surface tension values for the sample solutions are shown in the following table:

Concentration
(
mg/L)

Log10Concentration

Mean Surface Tension (mN/m)

Solution pH

1.021 x 103

3.009

30.7

7.33

306.2

2.486

30.7

6.92

102.1

2.009

31

6.54

30.62

1.486

31.5

6.11

10.21

1.009

34.7

6.24

3.062

0.486

42.2

6.19

1.021

0.009

54.8

6.17

0.3062

-0.514

71.0

6.23

0.1021

-0.991

71.7

6.33

Conclusions:
Under the study conditions, the critical micelle concentration of the test substance was determined to be 7.9 mg/L at 20.0 ± 0.5 °C.
Executive summary:

A study was conducted to determine the water solubility of the test substance using ring method, according to OECD Guideline 115 and EU Method A.5. Under the study conditions, the critical micelle concentration of the test substance was determined to be 7.9 mg/L at 20.0 ± 0.5°C (Envigo, 2018).

Description of key information

The water solubility was determined using the ring method according to OECD Guideline 115 and EU Method A.5 (Envigo, 2018).

Key value for chemical safety assessment

Water solubility:
7.9 mg/L
at the temperature of:
20 °C

Additional information

(CMC)

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