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Registration Dossier
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EC number: 201-796-4 | CAS number: 88-09-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1948
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The Metabolism of Some Branched Chain Aliphatic Acids
- Author:
- Dziewiatkowski, D. D., Venkataraman, A. and Lewis, H. B.
- Year:
- 1 949
- Bibliographic source:
- Dziewiatkowski, D. D., Venkataraman, A. and Lewis, H. B. (1949). The Metabolism of Some Branched Chain Aliphatic Acids. Journal of Biological Chemistry, 178(1), 169 - 177.
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- No guideline was available at the time the study was undertaken. Young male rabbits (2 - 4 kg) were housed in metabolism cages and were provided with a uniform diet of commercial rabbit chow or oat and cabbage. The sodium salt of the registered substance was injected subcutaneously or provided orally on day 0 at 1 g and urine was collected at 24-hour intervals (for at least 4 days). 0.1 g of the sodium salt of the registered substance was administered to rats. Standard procedures were used to analyse the urine, including modified Kjeldahl (total nitrogen), Folin (creatinine), Folin and Benedict-Denis (partition of urinary sulfur), and the procedure of Maughan, Evelyn, and Browne (1938). See Dominic, Dziewiatkowski, and Howard (1945) for a detailed description of the methodology.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylbutyric acid
- EC Number:
- 201-796-4
- EC Name:
- 2-ethylbutyric acid
- Cas Number:
- 88-09-5
- Molecular formula:
- C6H12O2
- IUPAC Name:
- 2-ethylbutyric acid
- Test material form:
- not specified
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Sex:
- male
Administration / exposure
- Route of administration:
- other: Oral and subcutaneous injection
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- Daily administration for a period of 4 days.
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 mg/kg bw/day (nominal)
- Remarks:
- Control
- Dose / conc.:
- 0.1 other: g
- Remarks:
- As sodium salt / rats
- Dose / conc.:
- 1 other: g
- Remarks:
- As sodium salt / rabbits
- Control animals:
- yes
- Details on dosing and sampling:
- Urine collected in 24-hour periods for analysis.
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Large amounts of glucuronic acid were excreted in rabbit urine that corresponded to 25 - 52 % of the 1 g 2-ethylbutyric acid ingested. Ketone derivatives, such as methylpropyl ketone, were not isolated in urine in increased amounts. At 0.1 g, glucuronic acid excretion in rats was increased by 22 to 49 %.
Applicant's summary and conclusion
- Conclusions:
- The sodium salt of 2-ethylbutyric acid was administered to male rabbits and rats orally or by subcutaneous injection in a 4-day in vivo experiment. 2-Ethylbutyric acid was discovered to be excreted unchanged in the urine in combination with glucuronic acid at 22 - 52 % of the total amount ingested. This result is suggestive of the registered substance being somewhat difficult to oxidise. Ketone derivatives such as methylpropyl were not identified, however, the possibility of catabolism occurring by such pathways was not ruled out.
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