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EC number: 201-796-4
CAS number: 88-09-5
combined experiment was undertaken to determine the repeated dose
toxicity and developmental / reproductive toxicity of 2-ethylbutyric
acid in male and female rats. Animals were administered the substance in
a corn oil vehicle via oral gavage once per day for a total of 42 days
at doses of 0 (control), 10, 50, or 250 mg/kg bw/day. The experiment was
performed in line with Good Laboratory Practise (GLP) and OECD Guideline
422 (Combined Repeated Dose Toxicity Study with the Reproduction /
Developmental Toxicity Screening Test).
mortality was recorded over the duration of the test that was related to
2-ethylbutyric acid. Transient salivation in males / females (250 mg/kg
bw/day); decreased white blood cell count (50 mg/kg bw/day) and platelet
count (250 mg/kg bw/day) in males; increased kidney weight in males /
females (250 mg/kg bw/day); decreased live pups on day 0 and 4 of
lactation (250 mg/kg bw/day); and decreased birth index and live birth
index (250 mg/kg bw/day) was recorded. No significantly negative effects
were observed in males and females relating to body weight gain; food
intake; blood chemistry; necropsy; histopathology; and reproductive
parameters (e.g. estrous cycle, copulation index). There were no
treatment-related changes in body weight, external appearance, and
necropsy findings in rat pups.
acid was determined to have a NOAEL of 250 and 50 mg/kg bw/day for
reproductive toxicity and developmental toxicity, respectively. A NOAEL
for repeated dose toxicity was concluded to be 10 mg/kg bw/day in males
and 50 mg/kg bw/day in females.
No treatment-related change in external
appearance. Number of live pups at 250 mg/kg bw/day was lower than
control (0 mg/kg bw/day) and other treatment groups. No
treatment-related change in body weight.
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