Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-796-4
CAS number: 88-09-5
acid was shown to have a No Observed Adverse Effect Level (NOAEL) of 300
mg/kg bw/day in rats as part of a 14-day repeated dose toxicity (oral)
experiment. A combined repeated dose and reproductive / developmental
toxicity experiment was performed for 2-ethylbutyric acid over a 42-day
period, in which there was a reported decrease in white blood cells at
50 mg/kg bw/day and in platelet count at 250 mg/kg bw/day in male rats.
Following necropsy, kidney weight was reported to be significantly
higher at 250 mg/kg bw/day in male and female rats. The NOAEL was
subsequently considered to be 10 mg/kg bw/day in males and 50 mg/kg
bw/day in females. The results of this experiment have been selected for
the purpose of the endpoint conclusion given that they are more
conservative and they have been obtained in a key study (Klimisch score
No treatment-related change in external
appearance. Number of live pups at 250 mg/kg bw/day was lower than
control (0 mg/kg bw/day) and other treatment groups. No
treatment-related change in body weight.
combined experiment was undertaken to determine the repeated dose
toxicity and developmental / reproductive toxicity of 2-ethylbutyric
acid in male and female rats. Animals were administered the substance in
a corn oil vehicle via oral gavage once per day for a total of 42 days
at doses of 0 (control), 10, 50, or 250 mg/kg bw/day. The experiment was
performed in line with Good Laboratory Practise (GLP) and OECD Guideline
422 (Combined Repeated Dose Toxicity Study with the Reproduction /
Developmental Toxicity Screening Test).
mortality was recorded over the duration of the test that was related to
2-ethylbutyric acid. Transient salivation in males / females (250 mg/kg
bw/day); decreased white blood cell count (50 mg/kg bw/day) and platelet
count (250 mg/kg bw/day) in males; increased kidney weight in males /
females (250 mg/kg bw/day); decreased live pups on day 0 and 4 of
lactation (250 mg/kg bw/day); and decreased birth index and live birth
index (250 mg/kg bw/day) was recorded. No significantly negative effects
were observed in males and females relating to body weight gain; food
intake; blood chemistry; necropsy; histopathology; and reproductive
parameters (e.g. estrous cycle, copulation index). There were no
treatment-related changes in body weight, external appearance, and
necropsy findings in rat pups.
acid was determined to have a NOAEL of 250 and 50 mg/kg bw/day for
reproductive toxicity and developmental toxicity, respectively. A NOAEL
for repeated dose toxicity was concluded to be 10 mg/kg bw/day in males
and 50 mg/kg bw/day in females.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again