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Dissociation constant

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Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
June 21 - August 13, 2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well described GLP compliant study conducted to recognized international test guidelines
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
yes
Dissociating properties:
not determined
No.:
#1
pKa:
2.96
Temp.:
20 °C
Conclusions:
pKa is 2.96
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
July 12 - August 19, 2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well described GLP compliant study conducted to recognized international test guidelines
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
yes
Dissociating properties:
not determined
No.:
#1
pKa:
2.5
Temp.:
20 °C
Conclusions:
pKa is 2.5
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
June 14 - August 10, 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well described GLP compliant study conducted to recognized international test guidelines
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
yes
Dissociating properties:
not determined
No.:
#1
pKa:
2.88
Temp.:
20 °C
Conclusions:
pKa is 2.88
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
July 7 - August 19, 2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well described GLP compliant study conducted to recognized international test guidelines
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
yes
Dissociating properties:
not determined
No.:
#1
pKa:
3.17
Temp.:
20 °C
Conclusions:
pKa is 3.17
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
June 14 - August 19, 2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well described GLP compliant study conducted to recognized international test guidelines
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
yes
Dissociating properties:
not determined
No.:
#1
pKa:
2.68
Temp.:
20 °C
Conclusions:
pKa is 2.68

Description of key information

The dissociation constants for the 5 aromatic sulphonic acids range from 2.5 to 3.2 at 20C.

Key value for chemical safety assessment

pKa at 20°C:
3.2

Additional information