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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1962
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Not a guideline study; some details on methodology, but concentration of test substance that the animals were exposed to is not reported. Indicated only as "saturated air".
Justification for type of information:
Read-across from supporting substance (structural analogue or surrogate)

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
HF Smythe, CP Carpender, CS Weil, UC Pozzani, JA Striegel
Year:
1962
Bibliographic source:
American Industrial Hygiene Association Journal 23: 95-107

Materials and methods

Principles of method if other than guideline:
Exposure to concentrated vapour is continued for time periods in a logarithmic series with a ratio of the two extending from 15 minutes to 8 hours until the inhalation period killing about half the number of rats within 14 days of observation is defined.
GLP compliance:
no
Test type:
fixed concentration procedure

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): benzenesulfonic acid
- Substance type: organic
- Physical state:
- Analytical purity: not indicated
- Lot/batch No.: not indicated

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
For exposures of 2, 5 or 10 minutes, a static technique was used by saturating the air with 50-100 g of test substance for 24 hours in a closed chamber. For exposures beyond 10 minutes a flowstream of saturated vapour was used.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
>= 0.25 - <= 8 h
Concentrations:
Not reported. Air was saturated with 50-100 g of test substance
No. of animals per sex per dose:
3
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: no
- Other examinations performed: none reported

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
>= 50 - ca. 100 other: mg
Based on:
test mat.
Exp. duration:
8 h
Mortality:
3 of 6 animals died within 14 days after an 8 hour exposure. No deaths were reported for shorter duration exposures (i.e, 15, 30, 45 minutes; and 1, 2 and 4 hours).

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information under saturated air conditions Criteria used for interpretation of results: expert judgment
Conclusions:
3 of 6 animals died within the 14-day observation period following an 8 hour exposure to a saturated air vapour of test substance