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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1968-04-23
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to the OECD Guideline, Pre GLP study. Not a full study report.
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1968
Report Date:
1968

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
6 animals were used for study instead of 10 (5 male and 5 female animals)
Principles of method if other than guideline:
None
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Sodium Cumene Sulphonate
- Molecular formula (if other than submission substance): C9-H12-O3-S.Na
- Molecular weight (if other than submission substance): Not available
- Substance type: Pure active substance
- Physical state: Not available
- Analytical purity: See below
- Impurities (identity and concentrations): See below
- Composition of test material, percentage of components: See below
- Isomers composition: See below
- Purity test date: See below
- Lot/batch No.: See below
- Expiration date of the lot/batch: See below
- Stability under test conditions: Not available
- Storage condition of test material: Not available
- Other: None

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Not available
- Age at study initiation: Not available
- Weight at study initiation: 2703 grams (Abraded skin), 2730 grams (Intact skin)
- Fasting period before study: Not available
- Housing: Not available
- Diet (e.g. ad libitum): Not available
- Water (e.g. ad libitum): Not available
- Acclimation period: Not available


ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not available
- Humidity (%): Not available
- Air changes (per hr): Not available
- Photoperiod (hrs dark / hrs light): Not available


IN-LIFE DATES: 1968-04-23

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
TEST SITE
- Area of exposure: Not available
- % coverage: Not available
- Type of wrap if used: Not available


REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not available
- Time after start of exposure: Not available


TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 ml/kg bw
- Concentration (if solution): Not available
- Constant volume or concentration used: yes
- For solids, paste formed: Not available


VEHICLE
- Amount(s) applied (volume or weight with unit): Not available
- Concentration (if solution): Not available
- Lot/batch no. (if required): Not available
- Purity: Not available
Duration of exposure:
Not available
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
Total 6 animals were taken for the study. Sex was not mentioned.
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Not available
- Necropsy of survivors performed: Not available
- Other examinations performed: Clinical signs, body weight
Statistics:
None

Results and discussion

Preliminary study:
None
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
0/3 (Abraded skin), 0/3 (Intact skin)
Clinical signs:
Sodium Cumene Suphonate elicited moderate primary irritation on the test sites.
Body weight:
Normal body weight gain.
Gross pathology:
Not available
Other findings:
- Organ weights: None
- Histopathology: None
- Potential target organs: None
- Other observations: None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
The LD50 > 2000 mg/kg bw and test substance is considered practically non toxic.
Executive summary:

The LD50 was >2000 mg/kg bw. This test substance is practically non toxic.