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EC number: 222-222-9 | CAS number: 3390-61-2
1,3,5-trimethyl-1,1,3,5,5-pentaphenyltrisiloxane was tested in a reliable study for skin irritation/corrosion. The study was conducted according to OECD TG 404, and in compliance with GLP.
0.5 mL of 1,3,5-trimethyl-1,1,3,5,5-pentaphenyltrisiloxane was applied undiluted onto the skin of 3 rabbits and kept in contact with the skin for 4 hours under semi-occlusive dressing. The exposure area was evaluated for skin irritation/corrosion according to Draize scoring systhem at 60 minutes, 24, 48 and 72 hours after removal of the patch.
Very slight erythema was observed at 60 minutes post-treatment in all the test animals, but fully reversible within 24 hours. No oedema was noted in any of the rabbits. The test material, 1,3,5-trimethyl-1,1,3,5,5-pentaphenyltrisiloxane, was reported to be not irritating to rabbit skin.
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