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EC number: 222-222-9 | CAS number: 3390-61-2
In the key skin irritation study, conducted according to OECD TG 404, and in compliance with GLP, the test substance, 1,3,5-trimethyl-1,1,3,5,5-pentaphenyltrisiloxane, was reported to be not irritating to rabbit skin (LPT, 2002).
In the key eye irritation study, conducted according to OECD TG 405, and in compliance with GLP, the test substance, 1,3,5-trimethyl-1,1,3,5,5-pentaphenyltrisiloxane, was reported to be not irritating to rabbit eyes (LPT, 2002).
0.5 mL of 1,3,5-trimethyl-1,1,3,5,5-pentaphenyltrisiloxane was applied undiluted onto the skin of 3 rabbits and kept in contact with the skin for 4 hours under semi-occlusive dressing. The exposure area was evaluated for skin irritation/corrosion according to Draize scoring systhem at 60 minutes, 24, 48 and 72 hours after removal of the patch.
Very slight erythema was observed at 60 minutes post-treatment in all the test animals, but fully reversible within 24 hours. No oedema was noted in any of the rabbits. The test material, 1,3,5-trimethyl-1,1,3,5,5-pentaphenyltrisiloxane, was reported to be not irritating to rabbit skin.
Following single instillation of 0.1 mL of undiluted test material into the conjunctival sac of the right eye of 3 rabbits, no irritation was observed into the test eye of any of the animals. The cornea, iris and conjunctivae were not affected by the test material.
1,3,5-trimethyl-1,1,3,5,5-pentaphenyltrisiloxane was reported to be not irritating under the conditions of the study.
Based on the available data for 1,3,5-trimethyl-1,1,3,5,5-pentaphenyltrisiloxane, no classification for skin and eye irritation is required according to Regulation (EC) No. 1272/2008.
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