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EC number: 222-222-9 | CAS number: 3390-61-2
In the key acute oral toxicity study, conducted according to OECD TG 423, and in compliance with GLP, an LD50 value of >2000 mg/kg bw was reported (LPT, 2002).
In the acute oral toxicity study, conducted according to OECD TG 423, and in compliance with GLP, an LD50 value of >2000 mg/kg bw was reported (LPT, 2002).
A single dose of 2000 mg/kg bw of undiluted test substance was administered orally to 3 male and 3 female rats. Observations were made before and immediately, at 5, 15, 30 and 60 minutes, as well as at 3, 6, 24 hours after administration. Body weights were recorded before administration and thereafter in weekly intervals up to the end of the 14-day study. At the end of the study period all the animals were sacrificed, dissected and inspected macroscopically.
No mortality occurred during the 14-day study period. No signs of systemic toxicity were noted. No macroscopic abnormalities were observed at necropsy.
Based on the available data for 1,3,5-trimethyl-1,1,3,5,5-pentaphenyltrisiloxane, no classification is required for acute toxicity according to Regulation (EC) No. 1272/2008.
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