Registration Dossier

Diss Factsheets

Physical & Chemical properties

Vapour pressure

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
vapour pressure
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
Principles of method if other than guideline:
The result was obtained using an appropriate QSAR method (see attached QMRF and QPRF for details).

The model is an adaptation of the existing SRC model MPBPVPWIN v 1.43, which is a component of the EPI Suite. This existing model uses the normal boiling point as input. Whilst this method is good in principle, the model was developed using a wide range of organic chemicals and only a few organosilicon compounds. Therefore, a validation procedure was undertaken to assess the applicability of the model to organosilicon compounds. It was noted that the MBBPVPWIN model gave a systematic error; therefore, the current model was developed to correct this. The current model is a linear regression based QSAR, with the vapour pressure prediction from MPBPVPWIN as the descriptor. The adapted model applies to organosilicon substances
Temp.:
25 °C
Vapour pressure:
0 Pa
Conclusions:
A vapour pressure value of 1.3E-08 Pa at 25°C was obtained using an accepted calculation method. The result is considered to be reliable.

Description of key information

Vapour pressure [ 1,3,5-trimethyl-1,1,3,5,5-pentaphenyltrisiloxane]: 1.3E-08 Pa at 25°C (QSAR)

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

A vapour pressure value of 1.3E-08 Pa at 25°C was obtained using an appropriate calculation method. The result is considered to be reliable.

Categories Display