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Toxicity to terrestrial arthropods

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There are no data describing the long-term toxicity of the registered substance to terrestrial arthropods. However, an OECD TG 222 earthworm reproduction study is planned for the read-across substance, silsesquioxanes, phenyl. The earthworm is the standard organism for soil macroorganisms and there is no indication that arthropods would be any more susceptible.

In the interim period, before the data with phenyl silsesquioxanes become available, data are available for the siloxane decamethylcyclopentasiloxane (D5, CAS: 541 -02 -6) with terrestrial arthropods. A 28-day LC50 value of 813 mg/kg dry weight and a 28 day IC50 value of 767 mg/kg dry weight have been determined for the effects of the test substance on mortality and reproduction of Folsomia candida. A NOEC of 377 mg/kg dry weight has been determined by the reviewer on the basis of a visual examination of the data for both mortality and reproduction.

This data will be considered in the derivation of the PNECsoil of the registration substance.

Read-across of the terrestrial toxicity data for D5 to 1,3,5-trimethyl-1,1,3,5,5-pentaphenyltrisiloxane CAS 3390-61-2 is considered to be suitable to derive an interim hazard and risk assessment under REACH for the registration substance.

Refer to Section 6.3 for further discussion.