N-[[3,5-dichloro-2-fluoro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]carbamoyl]-2,6-difluorobenzamide

Melting point / freezing point

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

22 August 2000

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Remarks:

Study conducted in compliance with agreed protocols, with no or minor deviations from the standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and conducted under GLP conditions.

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Deviations:

no

GLP compliance:

yes

Type of method:

capillary method

Key result

Melting / freezing pt.:

156.2 °C

Atm. press.:

ca. 1 013 hPa

Decomposition:

no

Sublimation:

no

Table 1: Results

Material	Replicate	Temperature (°C)		Average melting point (°C)
		Soften	Melting point
Reference Substance	1	120.2	121.6	121.7*
	2	120.0	121.8
	3	120.2	121.8
Test Material	1	155.0	156.2	156.2
	2	155.0	156.2
	3	155.0	156.2

* The average melting point of benzoic acid is within 1 °C of the expected melting point of 122.2 °C.

Conclusions:

Under the conditions of the test, the test melting point of the test material was determined to be 156.2 °C.

Executive summary:

The melting point of the test material was determined in triplicate using Thomas Hoover capillary melting point apparatus in a GLP study conducted in accordance with test guideline EPA OPPTS 830.7200. The apparatus was allowed to cool between measurements. The test material was placed in a small capillary, packed and placed in the melting point apparatus. The temperature of the oil bath was slowly raised at approximately 0.4 to 0.8 °C/min. The temperature was recorded when the material softened and when it complexly melted. The apparatus was calibrated using benzoic acid. Under the conditions of the test, the test melting point of the test material was determined to be 156.2 °C.

Reference 2

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

11 October 2000 - 8 December 2001

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Remarks:

Study conducted in compliance with agreed protocols, with no or minor deviations from the standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and conducted under GLP conditions.

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Deviations:

no

GLP compliance:

yes

Type of method:

hot stages

Remarks:

differential scanning calorimetry

Key result

Melting / freezing pt.:

> 155 - < 157 °C

Decomposition:

yes

Decomp. temp.:

ca. 250 °C

Sublimation:

no

The DSC scan of the test material reported a melting point range of 155 - 157 °C. A representative thermogram is shown in Figure 1.

Conclusions:

Under the conditions of the test, the meltnig point of the test material was determined to be in the range of 155 to 157 °C.

Executive summary:

The melting point of the test material was determined in a study performed under GLP conditions and in line with the standardised guideline EPA OPPTS 830.7200 using the differential scanning calorimetry (DSC method). Under the conditions of the test, the melting point range of the test material was determined to be 155 - 157 °C.

Description of key information

Melting point 156.2 °C, capillary method, EPA OPPTS 830.7200, Busse 2000.

Melting point 155 - 157 °C, DSC method, EPA OPPTS 830.7200, Busse 2001.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

156 °C

Additional information

The melting point of the test material has been addressed using a weight of evidence, consisting of two GLP guideline studies. Both studies have been assigned a reliability score of 1, reliable without restrictions, in line with the principles of Klimisch et al. (1997). The studies are in agreement that the melting point of the test material lies in the range of 155 – 157 °C. The melting point has been reported as 156 °C.

In the first study (Busse, 2000) the melting point of the test material was determined in triplicate using Thomas Hoover capillary melting point apparatus in a GLP study conducted in accordance with test guideline EPA OPPTS 830.7200.

The test material was placed in a small capillary, packed and placed in the melting point apparatus. The temperature of the oil bath was slowly raised at approximately 0.4 to 0.8 °C/min. The temperature was recorded when the material softened and when it complexly melted. The apparatus was calibrated using benzoic acid. Under the conditions of the test, the test melting point of the test material was determined to be 156.2 °C.

In the second study (Busse, 2001) the melting point of the test material was determined in a study performed under GLP conditions and in line with the standardised guideline EPA OPPTS 830.7200 using the differential scanning calorimetry (DSC method).

Under the conditions of the test, the melting point range of the test material was determined to be 155 - 157 °C.