N-[[3,5-dichloro-2-fluoro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]carbamoyl]-2,6-difluorobenzamide

Oxidising properties

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

oxidising solids

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

10 August 2001 - 11 August 2001

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Remarks:

Study conducted in compliance with agreed protocols, with no or minor deviations from the standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and conducted under GLP conditions.

Qualifier:

according to guideline

Guideline:

other: EPA OPPTS 830.6314 (Oxidising or Reducing Action) (This guideline addresses the endpoint 'Oxidation reduction potential'; migrated from section 'Oxidising properties')

Deviations:

no

GLP compliance:

yes

Contact with:

other: Ammonium phosphate, potassium permanganate, zinc powder and water

Duration of test (contact time):

>= 1 - <= 24 h

Key result

Sample tested:

test mixture as specified

Parameter:

other: temperature rise

Remarks on result:

mixture does not ignite and burn

Remarks:

No significant changes in temperature were observed.

Results

No significant changes in temperature were observed, nor was any evidence of chemical incompatibility observed with the addition of any of the reagents.

Table 1: Temperature Measurements

Oxidizing/Reducing Agent	Temperature (°C)
	Initial	Addition	1 hour	2 hours	4 hours	24 hours
Ammonium phosphate	21.9	20.9	21.7	22.0	21.9	22.3
Potassium permanganate	21.8	21.8	21.9	22.1	22.0	22.3
Zinc powder	21.9	21.9	21.9	22.2	22.0	22.3
Water	22.0	21.8	21.9	22.3	22.0	22.3

Interpretation of results:

GHS criteria not met

Conclusions:

Under the condition of the test, no significant changes in temperature were observed, nor was any evidence of chemical incompatibility observed with the addition of any of the reagents.

Executive summary:

The oxidising and reducing action of the test material was determined in a GLP study performed in accordance with the standardised guideline EPA OPPTS 830.6314.

The oxidising or reducing action was determined by adding the test material to four separate flasks. 10 mL of water was added to three of the flasks to form a slurry. The fourth flask was left dry for the later addition of water as the test reagent. The initial temperature of the contents of each flask was recorded.

An aqueous potassium pennanganate solution. ammonium phosphate (monobasic), zinc dust, and water were added, one to each flask. After mixing the test material and reagents, the temperatures of the solutions were recorded. Observations of any chemical incompatibility or temperature rise were recorded. The temperature was recorded at 1, 2, 4 and 24 hour intervals.

Under the condition of the test, no significant changes in temperature were observed, nor was any evidence of chemical incompatibility observed with the addition of any of the reagents. The test material was determined to have no oxidising properties.

Reference 2

Endpoint:

oxidising solids

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

9 May 2001 - 11 May 2001

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Study conducted in compliance with agreed protocols, with no or minor deviations from the standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and conducted under GLP conditions.

Qualifier:

according to guideline

Guideline:

EU Method A.17 (Oxidising Properties (Solids))

Deviations:

no

GLP compliance:

yes

Contact with:

powdered cellulose

Key result

Sample tested:

test mixture as specified

Parameter:

burning time of reaction over a distance of 200 mm

Remarks on result:

mixture does not ignite and burn

Remarks:

Neither mixtures of 2:1, 1:1 or 1:2 test material/cellulose burned to completion.

Results

As neither mixture of 2:1, 1:1 or 1:2 test material/cellulose burned to completion in the preliminary test, the test material is considered to be non-oxidising.

The reference mixture burned vigorously to completion in 40 seconds. No further testing was therefore necessary.

Interpretation of results:

GHS criteria not met

Conclusions:

Under the conditions of the test, the test material was determined to have no oxidising properties.

Executive summary:

The oxidising properties of the test material were determined in a study performed under GLP conditions and in accordance with the standardised guidelines EU method A.17.

The dried test material (2 parts) was thoroughly mixed with dried cellulose (l part) and formed into a cone shaped pile of dimensions 3.5 cm (diameter of base) x 2.5 cm (height). The cone, on a non-combustible, non-porous surface was ignited with a gas burner. The vigour and duration of the combustion were observed, recorded and compared with that of a similarly prepared cone consisting of 3 parts of barium nitrate to 2 parts of cellulose. As the sample cone failed to burn to completion , cones consisting of the test material (l part) and cellulose (1 and 2 parts) were prepared and tested. Neither mixtures of 2:1, 1:1 or 1:2 test material/cellulose burned to completion.

Under the conditions of the test, the test material was determined to have no oxidising properties.

Description of key information

Not oxidising, EU Method A.17, Comb, 2001.

Not oxidising, EPA OPPTS 830.6314, Busse, 2001.

Key value for chemical safety assessment

Oxidising properties:

non oxidising

Additional information

The oxidising properties of the test material has been address using a weight of evidence, consisting of two GLP guideline studies. Both studies have been assigned a reliability score of 1, reliable without restrictions, in line with the principles of Klimisch et al. (1997). Both studies are in agreement that the test material does not possess oxidising properties.

In the first study (Comb, 2001) the oxidising properties of the test material were determined in a study performed under GLP conditions and in accordance with the standardised guidelines EU method A.17.

The dried test material (2 parts) was thoroughly mixed with dried cellulose (l part) and formed into a cone shaped pile of dimensions 3.5 cm (diameter of base) x 2.5 cm (height). The cone, on a non-combustible, non-porous surface was ignited with a gas burner. The vigour and duration of the combustion were observed, recorded and compared with that of a similarly prepared cone consisting of 3 parts of barium nitrate to 2 parts of cellulose. As the sample cone failed to burn to completion, cones consisting of the test material (l part) and cellulose (1 and 2 parts) were prepared and tested. Neither mixtures of 2:1, 1:1 or 1:2 test material/cellulose burned to completion.

Under the conditions of the test, the test material was determined to have no oxidising properties.

In the second study (Busse, 2001) the oxidising and reducing action of the test material was determined in a GLP study performed in accordance with the standardised guideline EPA OPPTS 830.6314.

The oxidising or reducing action was determined by adding the test material to four separate flasks. 10 mL of water was added to three of the flasks to form a slurry. The fourth flask was left dry for the later addition of water as the test reagent. The initial temperature of the contents of each flask was recorded.

An aqueous potassium pennanganate solution. ammonium phosphate (monobasic), zinc dust, and water were added, one to each flask. After mixing the test material and reagents, the temperatures of the solutions were recorded. Observations of any chemical incompatibility or temperature rise were recorded. The temperature was recorded at 1, 2, 4 and 24 hour intervals.

Under the condition of the test, no significant changes in temperature were observed, nor was any evidence of chemical incompatibility observed with the addition of any of the reagents. The test material was determined to have no oxidising properties.

Justification for classification or non-classification

In accordance with the criteria for classification as defined in Annex I (Classification and Labelling Requirements for Hazardous Substances and Mixtures), Regulation (EC) No. 1272/2008 (CLP), the substance does not require classification as oxidising.