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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23 Aug 2017 to 30 Jan 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
other: EC Guideline A.24 (HPLC Method)
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)
Remarks:
Health Care Inspectorate of the Ministry of Health, Welfare and Sport; Utrecht, The Netherlands
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
4,4'-[isopropylidenebis(4,1-phenyleneoxy)]dianiline
EC Number:
235-985-8
EC Name:
4,4'-[isopropylidenebis(4,1-phenyleneoxy)]dianiline
Cas Number:
13080-86-9
Molecular formula:
C27H26N2O2
IUPAC Name:
4,4'-[isopropylidenebis(4,1-phenyleneoxy)]dianiline

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
4.3
Temp.:
35 °C
pH:
7
Type:
log Pow
Partition coefficient:
4.9
Temp.:
35 °C
pH:
7
Remarks on result:
other: Log Kow for trace (0.1%) impurity

Any other information on results incl. tables

Conclusion

The HPLC method at pH 7 was applied for the determination of the partition coefficient (Pow) of 4,4'-[isopropylidenebis(4,1-phenyleneoxy)]dianiline. The Pow and log Pow values of the test item at pH 7 are summarized below.

Test Item

Pow

log Pow

Peak area
(%)

Major peak

1.8 x 104

4.3

99.9

Impurity

8.0 x 104

4.9

0.11

Applicant's summary and conclusion