4,4'-[isopropylidenebis(4,1-phenyleneoxy)]dianiline

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07 June 2017 to 18 July 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Deviations:

not specified

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187

Deviations:

not specified

GLP compliance:

yes (incl. QA statement)

Remarks:

The Department of Health of the Government of the United Kingdom

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

4,4'-[isopropylidenebis(4,1-phenyleneoxy)]dianiline

EC Number:

235-985-8

EC Name:

4,4'-[isopropylidenebis(4,1-phenyleneoxy)]dianiline

Cas Number:

13080-86-9

Molecular formula:

C27H26N2O2

IUPAC Name:

4,4'-[isopropylidenebis(4,1-phenyleneoxy)]dianiline

Results and discussion

Mass median aerodynamic diameter:

189.093 µm

Particle size

Particle size 1

Percentile:

D10

Mean:

46.848 µm

St. dev.:

0.739

Particle size 2

Percentile:

D50

Mean:

171.197 µm

St. dev.:

1.866

Particle size 3

Percentile:

D90

Mean:

401.832 µm

St. dev.:

4.009

Any other information on results incl. tables

Optical Microscope Conclusions

Standard visual observation:

Sample observed to be a polydispersed, off-white powder with clusters.

Observation using 3.2 objective lens:

The particles appeared to be irregular shaped crystals. The smallest individual particle size was approximately 3 µm and the largest individual size was approximately 432 µm.

Observation using 40 objective lens:

The sample was observed to be made up of single crystalline particles and agglomerated particles.

 

Laser Diffraction Conclusions

Summary of Results:

The results of the laser diffraction test conducted to determine the particle size of

4,4'-[isopropylidenebis(4,1-phenyleneoxy)]dianiline are summarised in table below. The analysis was conducted using the dry powder module (DPM).

Particle Size Analysis using dry powder module (DPM)	Average (µm)
Volume weighted mean	201.074
Median	171.197
Mode	211.034
MMAD(massmedianaerodynamicdiameter)	189.093
d10-10% of materialis	46.848
d50-50% of materialis	171.197
d90-90% of materialis	401.832
volume of sample <10.00 µm	0.96%

Full Test Results:

	RUN1	RUN2	RUN3	RUN4	RUN5	Average**
Volume weighted mean	200.031	203.357	203.809	198.817	199.354	201.074
Median	170.203	173.107	173.729	168.944	170.059	171.197
Mode	209.337	212.029	214.059	207.298	212.405	211.034
MMAD*	187.996	191.203	191.890	186.605	187.837	189.093
d10-10% of materialis	46.286	47.691	47.799	46.504	46.023	46.848
d50-50% of materialis	170.203	173.107	173.729	168.944	170.059	171.197
d90-90% of materialis	400.137	406.276	406.896	397.603	398.060	401.832

All results are in µm

* Mass median aerodynamic diameter

** Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.

0.96 % by volume of sample was seen to be < 10.00 µm.

 

Standard Deviation Results:

RunNo.	1	2	3	4	5	STDVP	%STDVP
d10-10% of materialis	46.286	47.691	47.799	46.504	46.023	0.739	1.6
d50-50% of materialis	170.203	173.107	173.729	168.944	170.059	1.866	1.1
d90-90% of materialis	400.137	406.276	406.896	397.603	398.060	4.009	1.0
d15.78-15.78% of materialis	66.058	67.784	67.827	66.004	65.639	0.945	1.4
GSD	2.577	2.554	2.561	2.560	2.591	0.013	0.5
MMAD	187.996	191.203	191.890	186.605	187.837	2.061	1.1

GSD = Geometric standard deviation of the lognormal particle size distribution (calculated from d50/d15.78)

STDVP = standard deviation of the population

% STDVP = percentage standard deviation of the population

 

Coefficient of variation for d50 is less than 3%; d10 and d90 are less than 5%. Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320-1 test standard.