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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
equivalent or similar to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
not applicable
GLP compliance:
yes (incl. certificate)
Type of method:
column elution method
Key result
Water solubility:
2.26 µg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
ca. 7
Remarks on result:
other:
Remarks:
Mean value of both columns
Water solubility:
2.08 µg/L
Temp.:
20 °C
pH:
ca. 7
Remarks on result:
other: Standard deviation: 0.133 µg/L
Remarks:
mean value (Column 1)
Water solubility:
2.44 µg/L
Temp.:
20 °C
pH:
ca. 7
Remarks on result:
other: Standard deviation: 0.136 µg/L
Remarks:
mean value (Column 2)
Details on results:
Difference of the relative standard deviation between both columns: 14.8 %. The validity criterion (mean of both determinations should not differ by more than 30 %) was met.

Twenty-three fractions were collected from column 1 and eleven fractions from column 2, which were used for the determination of the water solubility. From each fraction 10 mL were collected.

Conclusions:
The water solubility of Solvent violet 59 was determined to be lower than 2.26 µg/Lmeasured at 20 °C (pH-value approx. 7).
Executive summary:

The study was performed according to guideline OECD 105 by the column elution method. For the support material approximately 600 mg silica gel Chromosorb W/AW (0.15 - 0.18 mm; Merck) was transferred to a distilling flask. 21.6 mg of the test item was weighed into a 100 mL measuring flask. Acetone was added to dissolve the test substance and the flask was filled up to the mark with acetone. 5 mL of this solution were diluted up to 100 mL with acetone. 5 mL of this solution was added to the support material and the solvent was completely evaporated using a rotary evaporator. The support material was soaked in demineralized water and the suspension was poured into the water-filled micro column. After equilibration 10 mL fractions from the micro column were collected and their concentration. was determined by HPLC-MS analysis. The content of the Solvent violet 59 in the test item was 99.2 %. The water solubility of Solvent violet 59 was determined to be lower than 2.26 µg/L measured at 20 °C (pH-value approx. 7).

Description of key information

The water solubility of Solvent violet 59 was determined to be lower than 2.26 µg/Lmeasured at 20 °C (pH-value approx. 7).

Key value for chemical safety assessment

Water solubility:
2.26 µg/L
at the temperature of:
20 °C

Additional information

In a supporting study (Prokschy 2006) a water solubility of 4.9 µg/L was found.