Registration Dossier
Registration Dossier
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EC number: 229-066-0 | CAS number: 6408-72-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- no
- Other quality assurance:
- other: Not specified
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 5.3
- Temp.:
- 25 °C
- Remarks on result:
- other: pH value not reported
- Details on results:
- In order to ensure a stable performance of the HPLC column, the column temperature was set to 40 °C. The reference Pow-values in the OECD guideline presumably refer to 25 °C. Even though the column temperature was 40 °C, this temperature has no influence on the result of the determination. Therefore the Pow-value of the test item determined within this study also refers to 25 °C.
- Conclusions:
- The partition coefficient (logPow) of Solvent violet 59 was determined to be 5.3 at 25 °C and no pH-value was reported.
- Executive summary:
For Solvent violet 59 the partition coefficient was determined by the HPLC-method according to OECD TG 117. The partition coefficient was determined to be 5.3 at 40°C. No pH-value was reported. In order to ensure a stable performance of the HPLC column, the column temperature was set to 40 °C. The reference Pow-values in the OECD guideline presumably refer to 25 °C. Even though the column temperature was 40 °C, this temperature has no influence on the result of the determination. Therefore the Pow -value of Solvent violet 59 determined within this study also refers to 25 °C. All validity criteria were met.
Reference
Description of key information
The partition coefficient (logPow) of Solvent violet 59 was determined to be 5.3 at 25 °C. The HPLC method was applied.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.3
- at the temperature of:
- 25 °C
Additional information
In a supporting study (Prokschy 2006) using the quotient of solubility in water and in n-octanol the logPow was deteremined to be 4.99.
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