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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
no
Other quality assurance:
other: Not specified
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
5.3
Temp.:
25 °C
Remarks on result:
other: pH value not reported
Details on results:
In order to ensure a stable performance of the HPLC column, the column temperature was set to 40 °C. The reference Pow-values in the OECD guideline presumably refer to 25 °C. Even though the column temperature was 40 °C, this temperature has no influence on the result of the determination. Therefore the Pow-value of the test item determined within this study also refers to 25 °C.
Conclusions:
The partition coefficient (logPow) of Solvent violet 59 was determined to be 5.3 at 25 °C and no pH-value was reported.
Executive summary:

For Solvent violet 59 the partition coefficient was determined by the HPLC-method according to OECD TG 117. The partition coefficient was determined to be 5.3 at 40°C. No pH-value was reported. In order to ensure a stable performance of the HPLC column, the column temperature was set to 40 °C. The reference Pow-values in the OECD guideline presumably refer to 25 °C. Even though the column temperature was 40 °C, this temperature has no influence on the result of the determination. Therefore the Pow -value of Solvent violet 59 determined within this study also refers to 25 °C. All validity criteria were met.

Description of key information

The partition coefficient (logPow) of Solvent violet 59 was determined to be 5.3 at 25 °C. The HPLC method was applied.

Key value for chemical safety assessment

Log Kow (Log Pow):
5.3
at the temperature of:
25 °C

Additional information

In a supporting study (Prokschy 2006) using the quotient of solubility in water and in n-octanol the logPow was deteremined to be 4.99.