Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 92/69/EWG, B.1
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test animals

Species:
other: rat, Hsd Cpb:WU

Administration / exposure

Vehicle:
other: Undilluted as supplied

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 1 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 3
Male: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels: 1000 mg/kg:locomotor disturbance 2000 mg/kg: Symptoms of intoxication were first seen 1 to 15 minutes after treatment.They lasted up to day 3 and consisted of locomtor disturbance, dyspnea, retention of feces, blood crusted snout, salivation, and abdominal position. Three male rats from the high dose group died up to day 3 of the study.
Gross pathology:
Effects on organs:
No effects

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU