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EC number: 441-000-4 | CAS number: 121219-07-6 1-ETHOXY-2,3-DIFLUORBENZOL; 1-ETHOXY-2,3-DIFLUOROBENZENE; 2,3-DIFLUOROPHENETOL; DIPHOL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001-01-23 till 2001-01-30
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- 31st July 1992
- Deviations:
- no
- GLP compliance:
- not specified
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- The concentration of the test substance in the solution was determined in duplicate, after:
- 0, 45.25, 48, 54 and 70 hours (pH 4.0)
- 0, 48 and 51 hours (pH 7.0)
- 0, 48 and 51 hours (pH 9.0) - Buffers:
- Buffer solutions at pH 4.0, 7.0 and 9.0 were prepared. The pH of each buffer solution was checked before use. In addition each buffer solution was degassed using nitrogen. For each buffer solution, one replicate was performed in which an aliquot (0.0296 g for pH 4.0. 0.0291 g for pH 7.0 and 0.0302 g for pH 9.0) of the test substance was dissolved in 2.5 mL of methanol and make up to 250 mL with the buffer solution in a test bottle protected from light.
- Estimation method (if used):
- Arrhenius plot of Ln k versus 1/T (T expressed in Kelvin) was constructed from the data.
- Duration:
- 70 h
- pH:
- 4
- Temp.:
- 60 °C
- Initial conc. measured:
- 101 ng/L
- Duration:
- 70 h
- pH:
- 7
- Temp.:
- 60 °C
- Initial conc. measured:
- 98.9 ng/L
- Duration:
- 70 h
- pH:
- 9
- Temp.:
- 60 °C
- Initial conc. measured:
- 103 ng/L
- Number of replicates:
- 2
- Positive controls:
- not specified
- Negative controls:
- not specified
- Preliminary study:
- The abiotic degradation was estimated in a preliminary test. The determination was undertaken at three pH levels (pH 4.0, 7.0 and 9.0). The test was performed at 50°C and 75 °C under sterile conditions and protected from light. During the preliminary test the degradation, at each pH value indicated an hydrolysis lower than 50% after 2.4 hours and higher than 10% after 3 days. The test item was considered as hydrolytically unstable.
- Test performance:
- First determination (test 1) was performed at 50°C to cover approximately 20-70% hydrolysis. As the results of this test indicated a pseudo-first order reaction kinetic, the final test (test 3) was performed at 60°C and 75°C.
- Transformation products:
- not measured
- % Recovery:
- 38
- pH:
- 4
- Temp.:
- 60 °C
- Duration:
- 70 h
- % Recovery:
- 31
- pH:
- 7
- Temp.:
- 60 °C
- Duration:
- 51 h
- % Recovery:
- 36
- pH:
- 9
- Temp.:
- 60 °C
- Duration:
- 51 h
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.001 h-1
- DT50:
- 680 h
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.008 h-1
- DT50:
- 82.9 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.004 h-1
- DT50:
- 178 h
- Type:
- (pseudo-)first order (= half-life)
- Details on results:
- Please see the tables below for details.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Following advanced tests results according to EU Method C.7, the test item can be considered as hydrolytically unstable with: t1/2 = 680 h at 25°C for pH 4.0, t1/2 = 82.9 h at 25°C for pH 7.0 and t1/2 = 178 h at 25°C for pH 9.0.
- Executive summary:
The determination of the hydrolysis as a function of pH was based on the EEC-Directive 92/69 EEC, Part C, Methods for the determination of Ecotoxicity, C.7: “Abiotic degradation: Hydrolysis as a function of pH”. The test item was determined to be not hydrolytically stable at pH 4, 7 or 9 in the preliminary test.During the preliminary test the degradation, at each pH value indicated an hydrolysis lower than 50% after 2.4 hours and higher than 10% after 3 days. The hydrolysis rate was then determined at three different temperatures. First determination (test 1) was performed at 50°C to cover approximately 20-70% hydrolysis. As the results of this test indicated a pseudo-first order reaction kinetic, the final test (test 3) was performed at 60°C and 75°C. The values of the hydrolysis rate constant and t1/2 at 25°C for each pH were obtained by extrapolation. The values were found to be: hydrolysis rate constant = 0.00102 h-1 and t1/2= 680 h at 25°C for pH 4.0; hydrolysis rate constant = 0.00836 h-1 and t1/2= 82.9 h at 25°C for pH 7.0; hydrolysis rate constant = 0.00389 h-1 and t1/2=178 h at 25°C for pH 9.0.
Reference
Table 1: Hydrolysis as a function of pH (pH 4.0 at 60°C)
Sampling Time (hours) |
Measured pH |
Measured concentration (µg/mL) |
|||
First assay |
Second assay |
Mean |
Remaining concentration (%) |
||
0 |
3.97 |
102 |
99.5 |
101 |
100 |
45.25 |
3.92 |
59.5 |
60.0 |
59.8 |
59 |
48 |
3.95 |
51.5 |
44.2 |
47.9 |
47 |
54 |
3.92 |
42.6 |
42.7 |
42.7 |
42 |
70 |
3.90 |
38.6 |
38.9 |
38.8 |
38 |
Table 2: Hydrolysis as a function of pH (pH 7.0 at 60°C)
Sampling Time (hours) |
Measured pH |
Measured concentration (µg/mL) |
|||
First assay |
Second assay |
Mean |
Remaining concentration (%) |
||
0 |
6.95 |
98.4 |
99.3 |
98.9 |
100 |
48 |
6.92 |
41.0 |
38.6 |
39.8 |
40 |
51 |
6.92 |
31.9 |
30.1 |
31.0 |
31 |
Table 3: Hydrolysis as a function of pH (pH 9.0 at 60°C)
Sampling Time (hours) |
Measured pH |
Measured concentration (µg/mL) |
|||
First assay |
Second assay |
Mean |
Remaining concentration (%) |
||
0 |
8.97 |
103 |
103 |
103 |
100 |
48 |
8.97 |
49.2 |
49.7 |
49.5 |
49 |
51 |
8.95 |
38.8 |
33.0 |
35.9 |
36 |
Description of key information
Following advanced tests results according to EU Method C.7, the test item can be considered as hydrolytically unstable with: t1/2 = 680 h at 25°C for pH 4.0, t1/2 = 82.9 h at 25°C for pH 7.0 and t1/2 = 178 h at 25°C for pH 9.0 (reference 5.1.2 -1).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 82.9 h
- at the temperature of:
- 25 °C
Additional information
The determination of the hydrolysis as a function of pH was based on the EEC-Directive 92/69 EEC, Part C, Methods for the determination of Ecotoxicity, C.7: “Abiotic degradation: Hydrolysis as a function of pH”. The test item was determined to be not hydrolytically stable at pH 4, 7 or 9 in the preliminary test.During the preliminary test the degradation, at each pH value indicated an hydrolysis lower than 50% after 2.4 hours and higher than 10% after 3 days. The hydrolysis rate was then determined at three different temperatures. First determination (test 1) was performed at 50°C to cover approximately 20-70% hydrolysis. As the results of this test indicated a pseudo-first order reaction kinetic, the final test (test 3) was performed at 60°C and 75°C. The values of the hydrolysis rate constant and t1/2at 25°C for each pH were obtained by extrapolation. The values were found to be: hydrolysis rate constant = 0.00102 h-1 and t1/2= 680 h at 25°C for pH 4.0; hydrolysis rate constant = 0.00836 h-1 and t1/2= 82.9 h at 25°C for pH 7.0; hydrolysis rate constant = 0.00389 h-1 and t1/2=178 h at 25°C for pH 9.0 (reference 5.1.2 -1).
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