Registration Dossier

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2000-09-28 to 2000-10-04
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
OECD Guideline No. 105, adopted on
27th July 1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
EC Directive No. 92/69/EEC, A.6 of 31 July 1992
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
254 mg/L
Conc. based on:
test mat.
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
9
Details on results:
Preliminary test:
This test was performed at room temperature in vessels protected from light. The pH value of the water used was 7.13. The preliminary test indicated that the test substance was soluble in water with a solubility above 10 mg/L. On the basis of these results, the final solubility determination was undertaken using the flask method.
Flask method:
The test was performed at 20 ± 2 °C, in vessels protected from light. The solubility in water was found to be 254 ± 4 mg/L with a precision of 2 %. The water used had a pH value of 7.5. In the three replicate solutions prepared, the pH values were found to be, 9.00, 9.00 and 8.99 (replicates 1 to 3).




























































Replicate number



Water solubility at 20 °C (mg/L)



/ Sampling Time



First dilution



Second dilution



Mean (n=2)



Mean (n=6)



3 / T48h



254



259



257



 



2 / T72h



247



258



253



 



1 / T96h



252



255



254



 



 



 



 



 



253



 



 



 



SD



7.78



 



 



 



CV %



3


Conclusions:
The water solubility of the test item was determined to be 254 mg/L at 20 °C and pH 9.
Executive summary:



The water solubility was determined according to Directive 92/69/EEC method A.6 and OECD Guideline No. 105, adopted on 27th July 1995 using the shake flask method with HPLC analysis. A preliminary test was undertaken to determine the approximate water solubility. Based on the preliminary result, aliquots of test material, were weighed into three separate flasks. After addition of Milli-Q water to the flasks, they were shaken at 30 °C and, after standing at 20 °C for a period of not less than 24 hours, the contents of the flasks were filtered and the concentrations were determined by HPLC. The water solubility of the test substance was determined to be 254 mg/L at 20 °C and pH = 9.

Description of key information


The water solubility of the test item was determined to be 254 mg/L at 20 °C and pH 9.

Key value for chemical safety assessment

Water solubility:
254 mg/L
at the temperature of:
20 °C

Additional information


The water solubility was determined according to Directive 92/69/EEC method A.6 and OECD Guideline No. 105, adopted on 27th July 1995 using the shake flask method with HPLC analysis. A preliminary test was undertaken to determine the approximate water solubility. Based on the preliminary result, aliquots of test material, were weighed into three separate flasks. After addition of Milli-Q water to the flasks, they were shaken at 30 °C and, after standing at 20 °C for a period of not less than 24 hours, the contents of the flasks were filtered and the concentrations were determined by HPLC. The water solubility of the test substance was determined to be 254 mg/L at 20 °C and pH = 9.