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Environmental fate & pathways

Biodegradation in soil

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Experimental data on the biodegradation in soil of the test item (4,4'-methylenebis(2-methylcyclohexanamine); CAS 6864-37-5) are not available. The substance does not have a high potential for adsorption to soil. The log Kow is low (2.3, meas., see IUCLID Ch. 4.7). The measured adsorption coefficient of the charged molecule is also low (log Koc = 2.6 at 23 °C and pH 7; see IUCLID Ch. 5.4.1). The model CATALOGIC 301C v11.15 (OASIS Catalogic v5.13.1) was used to predict potential metabolites of the substance. The model predicted the substance to be not readily biodegradable, as well (39% removal in 28 d, based on BOD). The substance was within the applicability domain of the model. The model predicted 128 metabolites, identifying 37 metabolites as relevant degradation products in terms of PBT/vPvB assessment, with an estimated quantity of ≥ 0.1% (for details see ‘Attached background material’ of the respective Endpoint Study Record in IUCLID Ch. 5.2.1). 26 of these metabolites are not readily biodegradable (< 60% after 28 d, based on BOD), but all of these 37 metabolites have a log Kow < 3; therefore, a significant bioaccumulation potential is not expected. It can be concluded that none of these degradation products is potentially PBT/vPvB. Therefore, no biodegradation studies in soil will be provided.

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