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EC number: 229-962-1
CAS number: 6864-37-5
The substance did not cause skin
sensitisation in two in vivo studies.
No skin reactions were observed after
challenge in both test (0/15) and control animals.
guinea pig maximisation test was considered as key, as the study was
performed comparable to OECD guideline 406 (Thorgeirsson, 1978). The
pre-GLP study was conducted according to original description of the
GPMT. No positive control was used; however, several simultaneously
tested compounds were positive thus proving the sensitivity of the test
system. The induction concentration was selected because of systemic
toxicity reported in the literature. Intradermal and topical induction
was performed with 0.5% test compound in acetone, dermal challenge with
2% test compound in acetone. None of the animals (0/15) showed a
result of this study was supported by the skin painting test with guinea
pigs (BASF AG, 1956). In that study, no sensitising potential (0/10) was
observed (1st induction: undiluted, 2nd induction: 10%, challenge: 1%,
all open epicutaneous).
Classification, Labeling, and
Packaging Regulation (EC) No 1272/2008
The available test data are reliable and
suitable for classification purposes under Regulation (EC) No 1272/2008.
Based on this information, the substance is not considered to be
classified for skin sensitisation under Regulation (EC) No 1272/2008, as
amended for the twelfth time in Regulation (EU) 2019/521.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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