Registration Dossier
Registration Dossier
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EC number: 273-224-1 | CAS number: 68953-70-8 The complex combination of alkanolamines from the distillation of reaction products of ammonia and oxirane. It consists predominantly of triethanolamine, diethanolamine and higher amines from the reaction of triethanolamine and oxirane.
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No data available
Key value for chemical safety assessment
Additional information
In Annex IX of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on aquatic organisms.
According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or CLP Regulation (EC) No 1272/2008 or is assessed to be a PBT or vPvB.
The hazard assessment of the mixture "oxirane, reaction products with ammonia, distn. residues" reveals neither a need to classify the substance as dangerous for the environment, nor is it a PBT or vPvB substance.
The ACR approach according to ECETOC No. 91 (2003) indicates that a chronic NOEC would be greater than 1 mg/L. The results from short-term toxicity tests on fish, Daphnia and algae demonstrate that D. magna is the most sensitive trophic level tested. Therefore, it may be concluded that results from a long-term test in fish would not reveal a greater hazard than already determined by the available data.
Therefore, and for reasons of animal welfare, a long-term toxicity study in fish is not provided.
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