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EC number: 273-224-1 | CAS number: 68953-70-8 The complex combination of alkanolamines from the distillation of reaction products of ammonia and oxirane. It consists predominantly of triethanolamine, diethanolamine and higher amines from the reaction of triethanolamine and oxirane.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 19.09-21.10.1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Origin of data other than LLNA = 1988, i.e. before REACH Annex VII/VIII was in place with the LLNA being the standard requirement. The GPMT is however valid and sufficient to conclude on this endpoint.
Test material
- Reference substance name:
- 2,2',2''-nitrilotriethanol
- EC Number:
- 203-049-8
- EC Name:
- 2,2',2''-nitrilotriethanol
- Cas Number:
- 102-71-6
- Molecular formula:
- C6H15NO3
- IUPAC Name:
- 2,2',2''-nitrilotriethanol
- Details on test material:
- - Name of test material (as cited in study report): Triethanolamine
- Physical state: clear, colourless liquid
- Analytical purity: 98.9 %
- Impurities (identity and concentrations): 0.4 % DEA, 0,6 % Triethanolamineglycolether
- Purity test date: 14.07.1988
- Lot/batch No.: sample 838, B 255 A (03.06.1988)
- Stability under test conditions: in the dark
- Storage condition of test material: 20°C
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Pirbright-White
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund, SPF-Zucht
- Strain: Hoe: DHPK(SPFLac)
- Weight at study initiation: x = 313g (=100 %); xmin= 286g (- 8,6%); * xmax= 337g (+ 7,7%); n = 15
- Housing: 5/ cage
- Diet: ERKA-Mischfutter Nr. 8300 for guinea pigs and rabbits, ad libitum
- Water: Tap water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 50 +/- 20
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12/12
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- physiological saline
- Concentration / amount:
- intradermal induction: 2 %
dermal induction: unchanged
dermal challenge: 10 %
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- physiological saline
- Concentration / amount:
- intradermal induction: 2 %
dermal induction: unchanged
dermal challenge: 10 %
- No. of animals per dose:
- pretest: 6 (determination of the non-irritating concentration
determination of the intradermal tolerance: 3
control group 1: 5
control group 2: 5
treatment group: 10 - Details on study design:
- RANGE FINDING TESTS: (dermal occlusive on the flank skin): 100%, 10% and 1% in saline
The animal's fur was clipped and 0.5 ml of the test substance was applied on a patch that was fixed on the skin under occlusive condition for 24 hours. After 24 hours the patch was removed and the skin was assessed another 24 hiurs later for erythema and oedema reactions.
To study the intradermal tolerance of the test substance, the substance was injected in concentrations of 0.2 %, 1 % and 5 % intradermally in the skin of the back, each concentration at two seperate areas.
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 2 (intradermal) and 1 epicutaneous
- Exposure period: 48 hours (epicutaneous)
- Test groups: 2x 0.1 ml at a concentration of 2 % in 50% Freunds adjuvans; 2x 0.1 ml at a concentration of 2 % in NaCl 0.9 %; 2x 0.1 ml of 50% Freunds adjuvans (intradermal)
0.5 ml of the test substance or vehicle was applied on a 2 x 4 cm patch which was applied for 48 hours to the animal's skin under occlusive conditions
- Control group: 2x 0.1 ml of 50% Freunds adjuvans; 2x 0.1 ml NaCl 0.9 %; 2x 0.1 ml of 50% Freunds adjuvans (intradermal
- Site: skin of the back
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Test groups: 0.5 ml of the 10 % test substance or vehicle was applied on a 2 x 2 cm patch which was applied for 24 hours to the animal's skin under occlusive conditions
- Control group: 0.5 ml of the 10 % test substance in saline
- Site: flank skin
- Evaluation (hr after challenge): 48 hours, 72 hours
OTHER: Time scale:
day 0: determination of body weight
day 1: intradermal induction
day 9: dermal induction
day 11: evaluation of skin irritation
day 22: dermal challenge
day 23: removal of occlusive dressing
day 24: 1st evaluation
day 25: 2nd evaluation
Scoring:
equivalent to Draize scores - Challenge controls:
- yes
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 10 %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 48.0. Group: test group. Dose level: 10 %. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: none .
- Reading:
- 2nd reading
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- 10 %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 72.0. Group: test group. Dose level: 10 %. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: none.
Any other information on results incl. tables
Body weight development:
mean body weight gain:
control group: 30.8 %
Treatment group: 35.7 %
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Classification: not sensitizing
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