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Long-term toxicity to aquatic invertebrates

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Description of key information

No chronic effects on aquatic invertebrates are expected for AMIX TE

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
16 mg/L

Additional information

Experimental long-term toxicity data for AMIX TE (CAS 68953 -70 -8) are not available. ECETOC (2003) developed the Acute to Chronic Ratio (ACR) based on toxicity data from various tests with different aquatic species (fish and aquatic invertebrates). Depending on the applied pooling criteria ACR values (90%-ile) have been calculated for different aspects. The relevant ACRs have a range from 11.5 (narcotic mode of action) to 94.5 (substance data for individual species). As the key value for AMIX TE is rather high (48-h EC50 > 222 mg/L, BASF SE, 2010), the NOEC is expected to be larger than 1 mg/L. Therefore, it can be concluded that chronic effects are not expected.

A study on the long-term toxicity to aquatic invertebrates is available for the structurally similar substance 2,2’,2’’-Nitrilotriethanol (CAS 102 -71 -6). To determine the chronic toxicity of 2,2',2"-nitrilotriethanol to aquatic invertebrates, a non-GLP reproduction toxicity study was performed using Daphnia magna as test species. The test followed a method of the German Federal Environmental Agency which is similar to the OECD TG 211. The test was designed as a semi-static procedure with closed vessels and exposure period of 21 days. Test concentrations were analytically verified and deviated less than 20% from nominal concentrations. Parental mortality, number of offspring per animal and first appearance of offspring were determined. The most sensitive endpoint was parental mortality. The 21 -d NOEC for parental mortality was determined to be 16 mg/L. The 21 -d NOEC for reproduction was 125 mg/L, the NOEC for appearance of first offspring was 250 mg/L (Kuehn et al./UBA 1989; Kuehn et al., 1988).