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EC number: 230-811-7 | CAS number: 7328-17-8
Summary table of treatment related findings in the stomach for animals killed at the end of treatment:
Squamous Cell Hyperplasia -Nonglandular Region
Submucosal/Mucosal Inflammation – Nonglandular Region
Mucosal Necrosis/Erosion -Glandular Region
Number of tissues examined
Pancreatic lymph nodes:
Macroscopically enlarged pancreatic lymph nodes in some males treated at 225 mg/kg/day were assessed histologically. In all of them, slightly increased germinal centre development and slight to moderate plasmacytosis were detected.
Summary table of treatment related findings in the pancreatic lymph nodes for animals killed at the end of treatment:
Increased Germinal Centre Development
The study was performed according to OECD Guideline 422 with minor deviations, which did not compromise the integrity of the study.
Three groups of ten male and ten female rats received Ethoxy ethoxy ethyl acrylate at doses of 25, 75 and 225 mg/kg/day by oral gavage administration. Males were treated daily for two weeks before pairing, up to necropsy after a minimum of five consecutive weeks. Females were treated daily for two weeks before pairing, throughout pairing, gestation and until Day 13 of lactation
Oral administration of Ethoxy ethoxy ethyl acrylatewas well toleratedwith no mortalities and no adverse effects of treatment on clinical condition, sensory reactivity, grip strength, motor activity, body weight gain, food intake or blood chemistry measurements in males and females treated with Ethoxy ethoxy ethyl acrylate.
Microscopic findings in the stomach of males and females treated at 75 or 225 mg/kg/day are compatible with secondary (reactive) changes due to an irritant effect of the test item on the stomach when administered by oral gavage. Inflammatory lesions were present in the glandular and non-glandular region of the stomach.
Macroscopically enlarged local lymph nodes in males treated at 225 mg/kg/day show histological features suggestive of local immunostimulation, which could be secondary to the gastric inflammatory changes.
In addition, an increase in total and differential leucocyte counts were observed in males treated at 225 mg/kg/day which is likely secondary due to the minimal to moderate inflammatory changes observed at microscopic evaluation in the forestomach of 9/10 males in this group. However, no similar increase in leucocyte counts was detected in females treated at 225 mg/kg/day despite the minimal to slight microscopic stomach lesions observed in 9/10 females at this dose level.
A NOAEL and a LOAEL were established to 25- and 75 mg/kg bw/day, respectively both for effects related to local stomach inflammation observed in both sexes.
Furthermore a NOAEL for systemic toxicity at 225 mg/kg kg/day can be concluded.
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