Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-811-7 | CAS number: 7328-17-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-(2-ethoxyethoxy)ethyl acrylate
- EC Number:
- 230-811-7
- EC Name:
- 2-(2-ethoxyethoxy)ethyl acrylate
- Cas Number:
- 7328-17-8
- Molecular formula:
- C9H16O4
- IUPAC Name:
- 2-(2-ethoxyethoxy)ethyl acrylate
- Test material form:
- liquid
- Details on test material:
- Name of the test substance used in the study report: Aethyldiglykolacrylat
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weight: males 223 g, females 167 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- 0.5% aqueous CMC preparation and 2 - 3 drops Cremophor EL
Form of administration: emulsion
Concentrations used: 5.62, 6.81, 8.25, 10, 12.1, 14.7 and 17.8% (w/v) - Doses:
- 562, 681, 825, 1000, 1210, 1470 and 1780 µl/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 106 mg/kg bw
- Remarks on result:
- other: original value: LD50 ca. 1100 µl/kg
- Mortality:
- 562 and 681 µl/kg: no deaths; 825 µl/kg: 1/10 after 14 days; 1000 µl/kg: 3/10 after 14 days; 1210 µl/kg: 9/10 after 14 days; 1470 µl/kg: 9/10 after 14 days; 1780 µl/kg: 10/10 after 14 days
- Clinical signs:
- other: Dyspnea, apathy, partly abdominal position, staggering, atony, biting spasms, cyanosis, partly reddish feces and reddish-crusted noses (Ames blood test positive), poor general state
- Gross pathology:
- Heart: acute dilatation; acute congestive hyperemia; glandular stomach: mucosa diffus reddened; proventriculus: border thickening, purulent, fibrinous plaque; slight diverticula formation; adherences with diaphragm; indifferent margins of the liver
Any other information on results incl. tables
Mortality:
Dose (µl/kg) |
Conc. (%) |
Number of animals |
Died within |
||||
1 h |
24 h |
48 h |
7 d |
14 d |
|||
1780 |
17.8 |
5 male |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
5 female |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
||
1470 |
14.7 |
5 male |
0/5 |
4/5 |
4/5 |
4/5 |
4/5 |
5 female |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
||
1210 |
12.1 |
5 male |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
5 female |
0/5 |
4/5 |
4/5 |
4/5 |
4/5 |
||
1000 |
10.0 |
5 male |
0/5 |
3/5 |
3/5 |
3/5 |
3/5 |
5 female |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
||
825 |
8.25 |
5 male |
0/5 |
1/5 |
1/5 |
1/5 |
1/5 |
5 female |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
||
681 |
6.81 |
5 male |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
5 female |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
||
562 |
5.62 |
5 male |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
5 female |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
||
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 was ca. 1106 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
