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Registration Dossier
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EC number: 204-712-4 | CAS number: 124-76-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- A toxicologic and dermatologic assessment of cyclic and non-cyclic terpene alcohols when used as fragrance ingredients
- Author:
- Belsito D
- Year:
- 2 008
- Bibliographic source:
- Food and Chemical Toxicology 46, S1-S71
Materials and methods
- Principles of method if other than guideline:
- No data on test method
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Exo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
- EC Number:
- 204-712-4
- EC Name:
- Exo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
- Cas Number:
- 124-76-5
- Molecular formula:
- C10H18O
- IUPAC Name:
- 1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 200 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 4 300 - <= 6 200
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified (CLP Regulation EC no. 1272/2008)
- Conclusions:
- The acute oral LD50 value of the test substance is 5200 mg/kg bw in rats
- Executive summary:
The acute oral LD50 value of the test substance is 5200 mg/kg bw in rats with a 95 % confidence interval of 4300 -6200 mg/kg bw.
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