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Physical & Chemical properties

Partition coefficient

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partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Test procedure in accordance with national standard methods (OECD) without GLP.
according to guideline
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
Type of method:
HPLC method
Partition coefficient type:
Analytical method:
high-performance liquid chromatography
Key result
log Pow
Partition coefficient:
25 °C
ca. 6


Sample name Conc. of sample: 30495.02

Solution (mg/ml): 9.4

RT(1): 8.71

K (estimated): 2.3

logK: 0.360

log Pow (4): 4.9

log Pow of undecan-1-ol: 4.9 at 25 °C
Executive summary:

The log Pow of undecan-1 -ol was determined according to OECD 117.

The log Pow versus log K values of the reference substances (Thymol, Naphthalene, Benzyl benzoate, Bibenzyl, 1 -Dodecanol and Tetradecanol) was plotted (R² = 0.9862). The resulting equation was used to calculate the log Pow of the test substance: log Pow of undecan-1-ol: 4.9 at 25 °C.

Description of key information

The octanol-water partition coefficient of undecan-1-ol (log Kow) is 4.9.

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
20 °C

Additional information

The log partition coefficient of 4.9 was determined in a reliable study.

It is supported by a value of 4.72, taken from a reference source of non assignable reliability. Although the value is of non-assignable reliability in its own right, the result value is supported by the strong correlation in log Kow values across the C6 -24 alcohols Category (refer to the physicochemical Category Report). Using QSAR derived for the Category members, the predicted value of log Kow for undecan-1-ol is 4.73.

The value of 4.72, taken from literature for pure alcohol, is used in exposure modelling.

Discussion of trends in the Category of C6-24 linear and essentially-linear aliphatic alcohols:

As chain length increases, the free energy required for a molecule to dissolve becomes less favourable for larger molecules. The octanol-water partition coefficient increases with molecular weight because each additional -CH2- group makes the octanol phase more preferred over water in terms of relative solvation energy.