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Environmental fate & pathways

Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption
Remarks:
adsorption
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Estimation Programs Interface Suite by US EPA
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
KOCWIN Program (v2.00).
GLP compliance:
not specified
Type of method:
other: Log Kow method
Media:
soil
Specific details on test material used for the study:
- Name of test material (as cited in study report): Piperazine citrate / tripiperazine dicitrate- Molecular formula: C12H30N6•Cl2H16O14 - Molecular weight: 642.76 g/mole - Substance type: Organic - Physical state: Solid
Radiolabelling:
not specified
Test temperature:
25 deg C
Analytical monitoring:
not specified
Key result
Type:
Koc
Value:
16.3 L/kg
Temp.:
25 °C
Remarks on result:
other: log Koc=1.212
Validity criteria fulfilled:
not specified
Conclusions:
The Soil Adsorption Coefficient i.e Koc value of Piperazine Citrate was estimated using EPI suite KOCWIN Program (v2.00) program as Koc 16.3 L/kg (log Koc is 1.212) at 25 deg.C. This Koc value indicates that the substance Piperazine Citrate has a has a Negligible sorption to soil and sediment along with rapid migration potential to groundwater.
Executive summary:

The Soil Adsorption Coefficient i.e Koc value of Piperazine Citrate was estimated using EPI suite KOCWIN Program (v2.00) program as Koc 16.3 L/kg (log Koc is 1.212) at 25 deg.C. This Koc value indicates that the substance Piperazine Citrate has a Negligible sorption to soil and sediment

along with rapid migration potential to groundwater.

Description of key information

The Soil Adsorption Coefficient i.e Koc value of Piperazine Citrate was estimated using EPI suite KOCWIN Program (v2.00) program as Koc 16.3 L/kg (log Koc is 1.212) at 25 deg.C. This Koc value indicates that the substance Piperazine Citrate has a has a Negligible sorption to soil and sediment along with rapid migration potential to groundwater.

Key value for chemical safety assessment

Koc at 20 °C:
16.3

Additional information

Predicted data of adsorption endpoint for the target chemical Piperazine citrate (Cas no. 144-29-6) and studies fro its read across chemical were reviewed and are presented as weight of evidence approach below:  

In key study, the Soil Adsorption Coefficient i.e Koc value of Piperazine Citrate was estimated using EPI suite KOCWIN Program (v2.00) program as Koc 16.3 L/kg (log Koc is 1.212) at 25 deg.C (EPI Suite, 2016). This Koc value indicates that the substance Piperazine Citrate has a Negligible sorption to soil and sediment along with rapid migration potential to groundwater.

From predicted model Danish (Q)SAR data base (database developed by the National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency) indicate that the soil adsorption coefficient (Koc) value of Piperazine citrate is estimated to be 20.55/kg (log Koc =1.3128), indicating that it is has a Negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.

And read across Piperazine (Cas no. 110-85-0) experimental study from HSDB database;2016 indicate that the adsorption coefficient (Koc) of substance Piperazine was found to be 3.6 using a log Kow of 1.50 and a regression derived equation. This Koc value suggests that piperazine is expected to have very high mobility in soil.

Other study from European Union Risk Assessment Report – PIPERAZINE, 3rd Priority List Volume: 56; Final Report, 2005 for same read across (Cas no. 110-85-0) indicate that adsorption study which is performed with three different soils (loam, sand and sandy loam) using the batch equilibrium method (OECD Guidelines 106) (Geurts, 2003). The optimal soil solution ratio of 1:5 was used for the final sorption test. Equilibrium was reached after approximately 8 hours. During experiment the Kdvalues was found to be 7.9-20. This result indicate that sorption of piperazine to soil is not correlated to the organic carbon content of the soils. Thus study finally concluded that the not to adsorb to or partition into solids to any significant extent, but remained in the water phase.

Thus based on the above all studies and by applying weight of evidence approach it is concluded that the test substance Piperazine citrate (Cas no. 144-29-6) have Negligible sorption to soil/sediment means not adsorb in soil compartment thus very high mobility in soil.

[LogKoc: 1.212]