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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species, other
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
EPI Suite estimation database.
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material (as cited in study report): Piperazine citrate / tripiperazine dicitrate- Molecular formula: C12H30N6•Cl2H16O14 - Molecular weight: 642.76 g/mole - Substance type: Organic - Physical state: Solid
Radiolabelling:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fish
Route of exposure:
aqueous
Test type:
other: estimated
Water / sediment media type:
not specified
Nominal and measured concentrations:
No data available
Reference substance (positive control):
not specified
Key result
Type:
BCF
Value:
3.162 L/kg
Basis:
whole body w.w.
Calculation basis:
other: estimated
Remarks on result:
other: Other details not known

BCFBAF Program (v3.01) Results:

==============================

--------------------------------- BCFBAF v3.01 --------------------------------

Estimated Log BCF = 0.500 (BCF = 3.162 L/kg wet-wt)

Validity criteria fulfilled:
not specified
Conclusions:
Bioaccumulation concentration factor (BCF) for Piperazine Citrate is 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that Piperazine Citrate is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.
Executive summary:

Estimation Programs Interface Suite (EPI suite, 2016) was run to predict the bioconcentration potential of the test compound Piperazine citrate (CAS no. 144 -29 -6). The BCF of the substance was calculated using BCFBAF Program (v3.01) software. Bioaccumulation concentration factor (BCF) for Piperazine Citrate is 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that Piperazine Citrate is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.

Description of key information

Bioaccumulation concentration factor (BCF) for Piperazine Citrate is 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that Piperazine Citrate is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.

Key value for chemical safety assessment

BCF (aquatic species):
3.162 L/kg ww

Additional information

Estimation Programs Interface Suite (EPI suite, 2016) was run to predict the bioconcentration potential of the test compound Piperazine citrate (CAS no. 144 -29 -6). The BCF of the substance was calculated using BCFBAF Program (v3.01) software. Bioaccumulation concentration factor (BCF) for Piperazine Citrate is 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that Piperazine Citrate is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.