Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Adsorption / desorption:

The Soil Adsorption Coefficient i.e Koc value of Piperazine Citrate was estimated using EPI suite KOCWIN Program (v2.00) program as Koc 16.3 L/kg (log Koc is 1.212) at 25 deg.C. This Koc value indicates that the substance Piperazine Citrate has a Negligible sorption to soil and sediment

along with rapid migration potential to groundwater.

Additional information

Adsorption / desorption:

Predicted data of adsorption endpoint for the target chemical Piperazine citrate (Cas no. 144-29-6) and studies fro its read across chemical were reviewed and are presented as weight of evidence approach below:  

In key study, the Soil Adsorption Coefficient i.e Koc value of Piperazine Citrate was estimated using EPI suite KOCWIN Program (v2.00) program as Koc 16.3 L/kg (log Koc is 1.212) at 25 deg.C (EPI Suite, 2016). This Koc value indicates that the substance Piperazine Citrate has a Negligible sorption to soil and sedimentalong with rapid migration potential to groundwater.

From predicted model Danish (Q)SAR data base (database developed by the National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency) indicate that the soil adsorption coefficient (Koc) value of Piperazine citrate is estimated to be 20.55/kg (log Koc =1.3128), indicating that it is has a Negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.

And read across Piperazine (Cas no. 110-85-0) experimental study from HSDB database;2016 indicate that the adsorption coefficient (Koc) of substance Piperazine was found to be 3.6 using a log Kow of 1.50 and a regression derived equation. This Koc value suggests that piperazine is expected to have very high mobility in soil.

Other study from European Union Risk Assessment Report – PIPERAZINE, 3rd Priority List Volume: 56; Final Report, 2005 for same read across (Cas no. 110-85-0) indicate that adsorption study which is performed with three different soils (loam, sand and sandy loam) using the batch equilibrium method (OECD Guidelines 106) (Geurts, 2003). The optimal soil solution ratio of 1:5 was used for the final sorption test. Equilibrium was reached after approximately 8 hours. During experiment the Kdvalues was found to be 7.9-20. This result indicate that sorption of piperazine to soil is not correlated to the organic carbon content of the soils. Thus study finally concluded that the not to adsorb to or partition into solids to any significant extent, but remained in the water phase.

Thus based on the above all studies and by applying weight of evidence approach it is concluded that the test substance Piperazine citrate (Cas no. 144-29-6) have Negligible sorption to soil/sediment means not adsorb in soil compartment thus very high mobility in soil.