Registration Dossier
Registration Dossier
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EC number: 204-288-0 | CAS number: 118-93-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1980-07-03 to 1980-07-18
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: orientating information about the inhalation hazard; sufficient for evaluation of vapor exposure
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at 20°C. 12 young adult laboratory rats were exposed sequentially to the vapors generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 7 h. The exposure was subsequently repeated in the same manner. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during exposure, and the amount of air used during exposure. Group-wise documentation of clinical signs was performed over a 7 day study period. Body weight of groups was determined before the start of the study (according to Smyth, H.F. et al.: Am. Ind. Hyg. Ass. J. 23, 95-107, 1962).
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
Test material
- Reference substance name:
- 2'-hydroxyacetophenone
- EC Number:
- 204-288-0
- EC Name:
- 2'-hydroxyacetophenone
- Cas Number:
- 118-93-4
- Molecular formula:
- C8H8O2
- IUPAC Name:
- 1-(2-hydroxyphenyl)ethan-1-one
- Details on test material:
- - Name of the test substance (as cited in the report): o-Hydroxyacetophenon
- Substance type: organic
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 212. 5 - 235 g; females: 190.7 - 198 g
Administration / exposure
- Route of administration:
- other: inhalation of volatile parts of the test substance
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- Concentrations:
- 3.54 mg/L
- No. of animals per sex per dose:
- 3 (a total of 12 animals was used for the test)
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: Animals attempt to escape and showed eyelid closure as well as dyspnea during the treatment.
- Gross pathology:
- No gross internal lesions were detected.
Applicant's summary and conclusion
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