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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1980-06-27 to 1980-07-1
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well-documented, scientifically acceptable study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report Date:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of the test substance (as cited in the study report): o-Hydroxyacetophenon

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: males: 182 g; females: 162 g
- Fasting period before study: 15 - 20 hours before application
- Diet: ad libitum, "Herilan MRH-Haltung" (H. Eggersmann KG)

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 14.7, 21.5, 31.6, 46.4 and 50 % (g/V)

MAXIMUM DOSE VOLUME APPLIED: 13.6 mL/kg
Doses:
1470, 2150, 3160, 4640, 6810 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 700 mg/kg bw
Based on:
test mat.
Mortality:
Male animals: 1470 mg/kg: 1/5 after 14 days; 2150 mg/kg: 0/5 after 14 days; 3160 mg/kg: 3/5 after 14 days; 4640 mg/kg: 4/5 after 14 days; 6810 mg/kg: 5/5 after 14 days
Female animals: 1470 mg/kg: no deaths; 2150 mg/kg: 2/5 after 14 days; 3160 mg/kg: 5/5 after 14 days; 4640 mg/kg: 4/5 after 14 days; 6810 mg/kg: 5/5 after 14 days
Clinical signs:
Animals showed dyspnea, apathy, abnormal position, staggering, atony, missing pain- and corneal reflexes, narcotic-like state, spastic gait, ruffled fur, exsiccosis, salivation and a poor general state.
Body weight:
Mean body weights after 14 days were 274 g (males) and 228 g (females). Animals gained weight throughout the study period.
Gross pathology:
Animals that died before end of the study period showed an acute congestive hyperemia and an acute dilatation of the right side of the heart. The stomach was atonic and liquid content was observed. The liver showed a loam yellow colour and was reddish mottled. Furthermore partly severe broadened peripher loam-yellow lobular pattern was observed.
Sacrificed animals did not show any gross internal lesions during necropsy.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information