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Short-term toxicity to aquatic invertebrates

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Description of key information

Acutely harmful to aquatic invertebrates.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
56.5 mg/L

Additional information

Acute toxic effects of 2-hydroxyacetophenone (CAS 118-93-4) to aquatic invertebrates were studied in a GLP study following the TSCA Environmental Effects Testing Guideline 797.1300 using Daphnia magna as test species (Hoechst Celanese Corporation, 1996, J9602007a). Based on nominal test concentrations the 48-h EC50 was determined to be 56.5 mg/L.

The result is supported by an acute toxicity test with the seawater mysid, Mysidopsis bahia (Hoechst Celanese Corporation, 1996, J9602007c), which resulted in an 96 h EC50 of 44.2 mg/L, indicating toxic effects of the substance to freshwater and marine invertebrates to be of an equivalent magnitude. According to REACh guidance Chapter R.10 the data for Daphnia is preferred in terms of chemical safety assessment.


2-hydroxyacetophenone is concluded to be acutely harmful to aquatic invertebrates.