Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-817-8 | CAS number: 2243-62-1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo
- Remarks:
- Type of genotoxicity: other: Unpublished data of "Berufsgenossenschaft der chemischen Industrie" cited in ´Toxikologische Bewertung; Ausgabe 05/90; 1,5-Naphthylendiamin; Berufsgenossenschaft der chemischen Industrie´).
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Unpublished data of "Berufsgenossenschaft der chemischen Industrie" cited in ´Toxikologische Bewertung; Ausgabe 05/90; 1,5-Naphthylendiamin; Berufsgenossenschaft der chemischen Industrie´). .
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other: Unpublished data of "Berufsgenossenschaft der chemischen Industrie" cited in ¿Toxikologische Bewertung; Ausgabe 05/90; 1,5-Naphthylendiamin; Berufsgenossenschaft der chemischen Industrie¿).
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
- Remarks:
- Unpublished data of "Berufsgenossenschaft der chemischen Industrie" cited in ´Toxikologische Bewertung; Ausgabe 05/90; 1,5-Naphthylendiamin; Berufsgenossenschaft der chemischen Industrie´).
- Type of assay:
- other: DNA-binding assay
Test material
- Reference substance name:
- 1,5-naphthylenediamine
- EC Number:
- 218-817-8
- EC Name:
- 1,5-naphthylenediamine
- Cas Number:
- 2243-62-1
- Molecular formula:
- C10H10N2
- IUPAC Name:
- 1,5-naphthylenediamine
- Details on test material:
- IUCLID4 Test substance: other TS: purity 98.8 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- ca.220 g body weight.
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- 24 h
- Frequency of treatment:
- single dose
- Post exposure period:
- 24 h after oral application the livers were prepared
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg (radiolabelled substance = 3.6 mCi/kg)
Basis:
- No. of animals per sex per dose:
- 2 male rats
- Control animals:
- not specified
Examinations
- Tissues and cell types examined:
- other: Unpublished data of "Berufsgenossenschaft der chemischen Industrie" cited in ´Toxikologische Bewertung; Ausgabe 05/90; 1,5-Naphthylendiamin; Berufsgenossenschaft der chemischen Industrie´).
Results and discussion
Test results
- Sex:
- male
Any other information on results incl. tables
RS-Freetext:
no DNA-binding activity
Applicant's summary and conclusion
- Executive summary:
In a DNA binding study 2 male Sprague-Dawley-rats (ca. 220g b.w) recieved a single oral dose of 100 mg/kg (radiolabelled substance = 3.6 mCi/kg) of 1,5 -Naphthylenediamine.
The DNA and Chromatin-protein were isolated, purified and the specific radioactivity was measured. The results were 4,5, respectively 5,9 dpm/mg DNA.
According to the authors no indication for a DNA binding activity of 1,5 -Naphthyleneamin could be found.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
