Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-817-8 | CAS number: 2243-62-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline and GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
- Principles of method if other than guideline:
- Method: other: according to guideline 84/449/EWG, Amtsblatt der Europaeischen Gemeinschaften Nr. L251 vom 19.09.1984, 103
- GLP compliance:
- yes
- Test type:
- other: Acute toxicity: dermal, rat
- Limit test:
- yes
Test material
- Reference substance name:
- 1,5-naphthylenediamine
- EC Number:
- 218-817-8
- EC Name:
- 1,5-naphthylenediamine
- Cas Number:
- 2243-62-1
- Molecular formula:
- C10H10N2
- IUPAC Name:
- 1,5-naphthylenediamine
- Details on test material:
- Purity 98.4 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Cremophor EL
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw.
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortalities.
- Clinical signs:
- No systemic or local symptoms of toxicity were observed.
- Body weight:
- see: remarks on results
- Gross pathology:
- No patological-anatomical changes observed
Any other information on results incl. tables
Body weights in (g)
| Animal No: | Sex | Week |
||
| 0 | 1 | 2 | ||
| 1 | male | 270 | 286 | 295 |
| 2 | male | 263 | 267 | 281 |
| 3 | male | 244 | 255 | 276 |
| 4 | male | 250 | 285 | 284 |
| 5 | male | 240 | 284 | 267 |
| MW | 253 | 275 | 281 | |
| 6 | female | 199 | 185 | 200 |
| 7 | female | 198 | 199 | 205 |
| 8 | female | 199 | 214 | 216 |
| 9 | female | 192 | 194 | 190 |
| 10 | female | 198 | 193 | 204 |
| MW | 197 | 197 | 203 | |
MW= Media
Applicant's summary and conclusion
- Executive summary:
In an acute dermal toxicity study 5 male and 5 female Wistar-rats (median weight: 253; 197 g resp.) were treated with 2000 mg/kg of the test substance (in Cremophor EL). The application time was 24h and the observation period 14 days.
No systemic or local symptoms of toxicity were observed.
The LD 50 was > 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
