Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:
Migrated from Short description of key information:
406 Male guinea pigs were tested with the Maximisation test (MAGNUSSON and KLINGMAN) according to OECD guideline 406. The test was executed with following concentrations of the test substance: Intradermal Induction: 2,5% Topical Induction: 50% 1. Provokation: 50% 2. Provokation: 5% and 25 % The test substance was formulated with Cremophor EL (2% v/v) in sterile, physiological NaCl-solution. After the 1. provocation in 9 of 20 animals an obvious skin sensitization was observed with 50% test substance-formulation. After the 2. provocation with the 25% test substance-formulation in 10 animals and with the 5% test substance-formulation in 4 animals a skin sensitization was observed. The test substance was found to be sensitizing to the skin (Diesing 1989). No respiratory sensitization study is available.

Justification for classification or non-classification