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EC number: 203-459-7
CAS number: 107-07-3
In preliminary experiments 2 or more of 6 treated rats died after
exposure to saturated vapour (room temperature) for 8 h; no further
Compare these results with IHT studies (Section 7.2.2).
The study is comparable to the OECD Guideline 403 with acceptable
restrictions (limited documentation of results; males and females used
in the same dose group; partly limited documentation of methods, e.g. no
details about the test substance; nominal concentrations).
Six Sherman rats per dose level were exposed for 4 hours to
concentrations varied in a geometric progression increasing by a factor
of 2. The post exposure observation period was 14 days. At a
concentration of 32 ppm (107 mg/m³) 2 -4 out of 6 treated rats died. No
further details were reported in the result section. However, it can be
assumed that a concentration of 16 ppm resulted in no mortality or only
1 death in 6 treated rats and at a concentration of 62 ppm more than 4
out of 6 treated rats died.
Conclusion: Rough estimation of LC50 (4 h) in rats: 16 ppm (53 mg/m³) <
LC50 < 62 ppm (207 mg/m³).
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