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EC number: 203-459-7
CAS number: 107-07-3
Emesis was observed in the dogs the 1st 3 h after administration.
The study is comparable to OECD Guideline 417 but data are restricted
to plasma concentrations after i.v. application and the corresponding
Four beagle dogs were i.v. injected with 46 mg/kg bw and blood
concentration were measured 0, 0.08, 0.25, 0.5, 1.0, 2.0, 3.0, 4.0, 7.0,
and 24 h after administration. The plasma concentration immediately
after injection was 75 µg/ml; ca. 25 µg/ml were measured after 90 min;
and ca. 5 µg/ml 180 min after application.
Conclusion: In dogs the elimination half-life is 41 minutes after i.v.
application of 46 mg/kg bw.
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