Registration Dossier
Registration Dossier
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EC number: 203-459-7 | CAS number: 107-07-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a local lymph node assay (Ashby et al., (1995)) groups of mice received open applications of 0, 2.5, 5, or 10% of the test substance in the vehicle (acetone, olive oil, 4:1 v/v) to the dorsum of each ear; days 2 and 3 this procedure was repeated. Five days following the initiation of experiment the mice were injected i.v. with 3H-thymidine; the activity was measured as a function of incorporation into the draining auricular lymph nodes. The stimulation index was 1.2, 1.0, and 1.6, respectively. The results demonstrated that the test item is not sensitising (a positive response includes a stimulation index ≥ 3).
Furthermore, no sensitization was observed in a guinea pig maximisation test conducted by Lawrence et al., (1971).
Migrated from Short description of key information:
The test substance is not sensitizing to the skin.
Justification for classification or non-classification
Based on the available data, the test item is not subject to C&L according to Directive 67/548/EEC or the Regulation 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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