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EC number: 203-459-7
CAS number: 107-07-3
In a local lymph node assay (Ashby et al., (1995)) groups of mice
received open applications of 0, 2.5, 5, or 10% of the test substance in
the vehicle (acetone, olive oil, 4:1 v/v) to the dorsum of each ear;
days 2 and 3 this procedure was repeated. Five days following the
initiation of experiment the mice were injected i.v. with 3H-thymidine;
the activity was measured as a function of incorporation into the
draining auricular lymph nodes. The stimulation index was 1.2, 1.0, and
1.6, respectively. The results demonstrated that the test item is not
sensitising (a positive response includes a stimulation index ≥ 3).
Furthermore, no sensitization was observed in a guinea pig maximisation
test conducted by Lawrence et al., (1971).
Based on the available data, the test item is not subject to C&L
according to Directive 67/548/EEC or the Regulation 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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