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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets scientific standards with acceptable restrictions (no details about the test substance)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Principles of method if other than guideline:
LD50 in mice
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloroethanol
EC Number:
203-459-7
EC Name:
2-chloroethanol
Cas Number:
107-07-3
Molecular formula:
C2H5ClO
IUPAC Name:
2-chloroethan-1-ol
Details on test material:
No details

Test animals

Species:
mouse
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
1 and 2% aqueous solution
Doses:
50, 64, 80, 100, 125 µl/kg bw
No. of animals per sex per dose:
5
Details on study design:
Post exposure observation period 14 days
Necropsy performed

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 120 mg/kg bw
Mortality:
Males more sensitive than females
Clinical signs:
>= 100 µl/kg bw: symptoms immediately after injection like increased respiration rate, then hunching position, atony, twitching, staggered gait, apathy, side or prone position; survivors without symptoms at day 4
<=80 µl/kg bw: increased respiration rate, hunching position, staggered gait; survivors without symptoms at day 3
Gross pathology:
greyish liver

Applicant's summary and conclusion

Conclusions:
LD50 in male and female mice combined was ca. 120 mg/kg bw after i.p. injection.
Executive summary:

Study meets scientific standards.

Five male and 5 female mice were i.p. injected with 50, 64, 80, 100, or 125 µl/kg bw; the post exposure observation period was 14 days. Clinical signs occurred immediately after injection. Males were more sensitive than females.

Conclusion: The LD50 in male and female mice combined was ca. 120 mg/kg bw after i.p. injection.