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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets scientific standards with acceptable restrictions (no details about the test substance)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Principles of method if other than guideline:
LD50 in mice
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloroethanol
EC Number:
203-459-7
EC Name:
2-chloroethanol
Cas Number:
107-07-3
Molecular formula:
C2H5ClO
IUPAC Name:
2-chloroethan-1-ol
Details on test material:
No details

Test animals

Species:
mouse
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
1 and 2% aqueous solution
Doses:
50, 64, 80, 100, 125 µl/kg bw
No. of animals per sex per dose:
5
Details on study design:
Post exposure observation period 14 days
Necropsy performed

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 120 mg/kg bw
Mortality:
Males more sensitive than females
Clinical signs:
>= 100 µl/kg bw: symptoms immediately after injection like increased respiration rate, then hunching position, atony, twitching, staggered gait, apathy, side or prone position; survivors without symptoms at day 4
<=80 µl/kg bw: increased respiration rate, hunching position, staggered gait; survivors without symptoms at day 3
Gross pathology:
greyish liver

Applicant's summary and conclusion

Conclusions:
LD50 in male and female mice combined was ca. 120 mg/kg bw after i.p. injection.
Executive summary:

Study meets scientific standards.

Five male and 5 female mice were i.p. injected with 50, 64, 80, 100, or 125 µl/kg bw; the post exposure observation period was 14 days. Clinical signs occurred immediately after injection. Males were more sensitive than females.

Conclusion: The LD50 in male and female mice combined was ca. 120 mg/kg bw after i.p. injection.